First Affiliated Hospital Of Wenzhou Medical University

This study compares two ways to perform rectal cancer surgery in women to see which leads to less bleeding and better recovery. About 200 female patients with mid-to-low rectal cancer will take part. The goal is to find the safest and most effective surgical technique for women.

This early-phase trial tests an experimental treatment called CBG131, made from a patient's own immune cells, for advanced stomach or pancreatic cancer that has a specific marker (CLDN18.2). About 18 adults will receive a single infusion of these engineered cells after mild chemo…

This study tests whether GLP-1 weight-loss drugs (semaglutide and tirzepatide) can improve sperm quality and fertility in obese men struggling to conceive. About 180 men will receive either lifestyle advice, semaglutide, or tirzepatide for 48 weeks. The main goal is to see if spe…

This study tests whether adding dextromethorphan to nidanib helps people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. About 60 adults aged 40 and older with mild to moderate lung damage will receive either the combination or a…

This study tests whether a 12-week steroid treatment works as well as the standard 24-week course for adults having their first episode of steroid-sensitive nephrotic syndrome, a kidney condition causing protein leakage and swelling. About 224 participants will be randomly assign…

This study tests a drug called risankizumab for people with a severe form of Crohn's disease that causes scarring and narrowing of the intestines. About 260 adults who have not improved with standard treatments will receive either the drug or a placebo. The goal is to see if the …

This study tests a new drug called inectolizumab combined with steroids in people newly diagnosed with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune disease that attacks the nerves. The goal is to see if the drug can help control the disease while allowing pat…

This study tests whether giving immunotherapy and chemotherapy at different times can help people with advanced non-small cell lung cancer (NSCLC) that lacks certain gene mutations. About 246 adults will be split into three groups: same-day treatment, chemotherapy two days before…

This study tests whether adding targeted radiation to standard chemotherapy and immunotherapy before surgery can improve outcomes for people with a common, high-risk breast cancer type (HR+/HER2-). About 302 participants will receive either chemo-immunotherapy alone or with radia…

This study looks at 140 people with coronary artery disease who need non-emergency non-cardiac surgery. Researchers want to see if it is safer and more effective to treat blocked heart arteries before or after the surgery. The goal is to reduce major heart problems like heart att…

This study compares a new, less invasive surgery that removes only the cancerous upper part of the stomach to the standard surgery that removes the entire stomach. The goal is to see if the new approach helps patients maintain more weight and have fewer side effects like acid ref…

This study tests a new, high-tech surgical system for people with knee osteoarthritis. The system uses 3D planning, custom 3D-printed guides, and augmented reality to help surgeons perform more precise knee realignment surgery. Researchers will compare this new approach to tradit…

This study is for people with a high-risk form of bladder cancer that has not responded to or cannot tolerate the standard BCG treatment. It compares a two-part treatment—an immunotherapy drug given through a vein plus a two-drug chemotherapy wash placed directly into the bladder…

This study tests three different digital foot care strategies, including AI-powered tools, to see which works best at preventing diabetic foot ulcers. Researchers will enroll 1,512 people with diabetes who are at high risk for foot ulcers. Participants will use smartphone apps to…

This study tests whether ondansetron, a drug typically used for nausea, can lower the risk and severity of side effects from immunotherapy in people with liver cancer. About 134 patients will receive ondansetron alongside their standard cancer treatment. The goal is to see if thi…

This study looks back at data from 400 liver cancer patients to build an AI system that predicts how well they will respond to a standard treatment (atezolizumab plus bevacizumab). The goal is to identify which patients are likely to benefit before starting therapy, avoiding unne…