Eunice Kennedy Shriver National Institute Of Child Health And Human Development (nichd)

This study looked at how the diabetes drugs glyburide and metformin work in pregnant women with gestational diabetes. 177 women between 20 and 32 weeks pregnant took part. The goal was to find the right dose and understand how these drugs control blood sugar and improve insulin f…

This study tested a drug called pegvisomant in children aged 2 to 18 with gigantism, a condition where the body makes too much growth hormone. The goal was to see if the drug could safely lower hormone levels and slow down abnormal growth. Participants received daily injections a…

This completed Phase 2 trial tested whether colchicine, an anti-inflammatory drug, can improve insulin resistance in 152 adults and adolescents with obesity. Participants took either colchicine or a placebo daily for 12 weeks. The study measured changes in insulin resistance and …

This study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…

This study looked at adrenal gland tumors to understand why they form, why some release extra hormones, and why some are cancerous. Researchers studied 690 people with known or suspected adrenal tumors. Participants underwent tests like blood draws, imaging scans, and urine colle…

This study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to track how the condition changes over time. Researchers measured bone density, lung and heart function, hearing, and movement abilities. The goal was to better …

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study looked at how depression in mothers affects their interactions with their babies and the child's development. Researchers observed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The goal was to understand differences i…

This study looked at people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was to learn more about these conditions, train doctors, and collect samples for future research. Participants received stand…

This study looked at how a mother's age, job status, and whether she had other children affect her interactions with her baby. Researchers watched 2,355 mothers and their infants when the babies were 5 months old, then checked the children's development at 20 and 48 months. The g…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This study looks at how early childhood relationships with caregivers affect the ability to form healthy, stable romantic partnerships in young adulthood. Researchers are following up with participants from a previous child development study, now aged 18 and older, who live with …

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study looked at how lifestyle factors like diet and health habits affect a couple's ability to conceive. Researchers followed 266 couples planning their first pregnancy, tracking how long it took to get pregnant and any early pregnancy losses. The goal was to better understa…

This study looked at how obesity and related metabolic changes affect bone development in 358 healthy girls aged 9-12. Researchers measured bone mass, density, and strength over two years. The goal is to understand these links to help prevent fractures and osteoporosis later in l…

This study followed nearly 5,000 U.S. teenagers from 10th grade into their early twenties to track how their health behaviors—like diet, exercise, substance use, and driving—changed over time. Researchers collected surveys, genetic samples, and neighborhood data to understand wha…

This study tested a new technique called speckle plethysmography to measure blood pressure continuously using light sensors on the fingers and toe. Forty healthy adults wore the sensors while doing tasks like slow breathing, math problems, and putting a hand in ice water. The goa…

This study followed 46 children with osteogenesis imperfecta (OI), a rare connective tissue disorder that causes frequent fractures and short stature. Researchers collected medical history, physical exams, hearing and dental tests, X-rays, bone scans, and genetic samples over sev…

This completed study at the NIH enrolled 96 children with known or suspected genetic disorders, including autism and Fragile X syndrome. The main goal was to give clinic staff hands-on experience and explore new research ideas. Participants received medical exams, lab tests, and …

This pilot study tested a noninvasive wearable device that measures breathing, heart rate, body temperature, and oxygen levels. Researchers wanted to see if it could help screen for and monitor respiratory infections like COVID-19. Forty healthy adults performed breathing tasks w…