Eunice Kennedy Shriver National Institute Of Child Health And Human Development (nichd)

This study looked at how two common diabetes pills, glyburide and metformin, work in pregnant women with gestational diabetes. The goal was to find the right doses and understand how they affect insulin and blood sugar. 177 pregnant women between 20-32 weeks took part. The result…

This study tested whether colchicine, a common anti-inflammatory medicine, could improve metabolism in people with obesity who have high inflammation and high insulin levels but not yet high blood sugar. About 152 adults and teens took colchicine or a placebo daily for 12 weeks. …

This study tested a drug called pegvisomant in children and teenagers with gigantism, a rare condition caused by too much growth hormone. The goal was to see if the drug could safely control hormone levels, slow excessive growth, and improve symptoms like headaches and fatigue. P…

This study followed 46 children with osteogenesis imperfecta (OI), a condition that causes fragile bones and short stature, to understand how the disease progresses and how genes affect it. Participants had regular checkups, scans, and tests over several years, but no new treatme…

This study looked at the genes and health patterns of people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. Researchers studied over 1,300 participants to find the genetic causes and improve diagnosis. The goal was to help families understand their r…

This study tested a new technique called speckle plethysmography to see if it can measure blood pressure changes continuously using sensors on the fingers and toe. Forty healthy adults participated and underwent activities like slow breathing, math problems, and an ice bath to ch…

This study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to learn how the condition affects their bodies over time. Researchers tracked bone health, movement, heart and lung function, hearing, and brain issues. The goal…

This study tested a noninvasive device that measures breathing, heart rate, body temperature, and oxygen levels. Researchers wanted to see if it could help screen and monitor respiratory infections like COVID-19. Forty healthy adults performed breathing tasks while the device was…

This study looked at how obesity and related metabolic changes affect bone development in 358 healthy girls aged 9-12. Researchers measured bone mass, density, and strength over two years using advanced imaging. The goal is to understand these links to help prevent fractures and …

This study tested whether two light-based technologies (fNIRS and DCS) can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a snug cap with li…

This study evaluated people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was not to test new treatments but to learn more about these conditions, improve doctor training, and collect samples for fut…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic disorder that affects how the body makes cholesterol. It causes birth defects and developmental delays. Researchers studied 130 patients and their mothers to better understand the disease, its complications, a…

This study looked at why adrenal gland tumors form and why some release extra hormones while others don't. Researchers studied 690 people aged 3 to 70 with known or suspected adrenal tumors. They used blood and urine tests, imaging scans, and genetic analysis to better understand…

This study followed nearly 5,000 U.S. teenagers from 10th grade through young adulthood (2009-2016) to learn how their health, habits, and risks change over time. Researchers collected surveys, physical measurements, and genetic data to understand what helps teens stay healthy or…

This study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their family members to learn more about these conditions.…

This study looks at how early childhood relationships with caregivers influence the formation of healthy, stable romantic partnerships in young adulthood. About 259 participants from a previous child development study and their live-in partners completed online surveys about thei…

This study looked at how a mother’s age, whether she works, and if she has other children affect her baby’s mental and social growth. Researchers watched 2,355 mothers and their babies at 5 months, then checked the children’s development at 20 months and again at 4 years old. The…

This study enrolled 96 children with known or suspected genetic disorders, including conditions like autism and Fragile X syndrome. The main goal was to give clinic staff hands-on experience and explore new research methods, not to provide treatment. Participants had medical exam…

This study looked at how depression changes the way mothers interact with their babies and how that affects the child's thinking, emotions, and development. Researchers filmed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The go…