Cancer Trials Ireland

This study tested a new drug, copanlisib, combined with the standard drug trastuzumab in 26 women with advanced HER2-positive breast cancer that had stopped responding to previous treatments. The goal was to find the safest dose and see if the combination could shrink tumors or s…

This study tested whether giving a combination of abiraterone acetate, prednisolone, and a hormone-blocking drug for about 4 months before radiation could shrink tumors and lower PSA in 45 men with high-risk localized prostate cancer. The goal was to improve treatment response be…

This study tested whether combining two drugs, Radium-223 and enzalutamide, is safe for men with advanced prostate cancer that has spread to bones and no longer responds to hormone therapy. Forty-five participants received the combination to track side effects and how long the ca…

This study aimed to find new ways to classify patients with a specific type of advanced colorectal cancer that does not respond well to standard treatments. Researchers analyzed tumor samples from 29 participants to identify patterns that could help predict how the disease will b…

This study looked at whether it's practical to routinely test tumor tissue from ovarian cancer patients for BRCA gene mutations. Researchers enrolled 200 patients with high-grade serous or endometrioid ovarian, fallopian tube, or primary peritoneal cancer. The goal was to see if …

This study looked at 76 people with advanced colorectal cancer that has a specific gene change (mutant K-ras). They received a combination of chemotherapy (FOLFOX) and a targeted drug (bevacizumab). The main goal was to find biological markers (biomarkers) that can predict how we…