Cancer Trials Ireland

This study tested a drug combination (abiraterone acetate plus prednisolone and hormone therapy) given before radiation in 45 men with high-risk localized prostate cancer. The goal was to see if the treatment could shrink tumors and lower PSA levels. The approach aims to improve …

This early-phase trial tested a combination of two drugs—copanlisib and trastuzumab—in 26 women with advanced HER2-positive breast cancer that had worsened after prior treatment. The goal was to find the safest dose and see if the combination could shrink tumors or slow disease p…

This study tested whether giving two drugs together—Radium-223 and enzalutamide—is safe for men with advanced prostate cancer that has spread to other parts of the body and is no longer controlled by standard hormone therapy. 45 men took part. The main goal was to track serious s…

This study tested whether it is practical to routinely check ovarian cancer tumors for BRCA gene mutations in the clinic. Researchers enrolled 200 patients with high-grade serous or endometrioid ovarian, fallopian tube, or primary peritoneal cancer. They used blood and tumor samp…

This study looked at whether a tumor gene test called the 21 gene Recurrence Score (OncotypeDx) changes doctors' recommendations for chemotherapy in women with early-stage, hormone receptor-positive breast cancer that has spread to lymph nodes. Researchers tracked how often chemo…

This completed study looked at 29 patients with a hard-to-treat form of advanced colorectal cancer. The goal was to find new ways to group these patients based on the biology of their tumors. This could help doctors choose more effective treatments in the future. The study did no…

This study looked at 76 adults with advanced colorectal cancer to find genetic markers that might predict how well a combination of chemotherapy (FOLFOX) and the drug bevacizumab works. The goal was to understand which patients benefit most, not to test a new cure. Participants h…