Routine BRCA testing for ovarian cancer patients proves feasible in irish study

NCT ID NCT06274541

Completed Knowledge-focused Sponsor: Cancer Trials Ireland Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether it is practical to routinely check ovarian cancer tumors for BRCA gene mutations in the clinic. Researchers enrolled 200 patients with high-grade serous or endometrioid ovarian, fallopian tube, or primary peritoneal cancer. They used blood and tumor samples to look for BRCA1/2 mutations, aiming to see if this approach works well for doctors and patients, and if it is cost-effective for the healthcare system.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BRCA1/2 genetic testing
What this could lead to: If successful, this could make BRCA testing a standard part of ovarian cancer care, helping doctors choose better treatments and informing family members about their cancer risk.
What could go wrong: This was a small pilot study focused on feasibility, not on patient outcomes. The results may not apply to other healthcare systems or populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer fallopian tube endometrioid adenocarcinoma fallopian tube neoplasm fallopian tube serous adenocarcinoma ovarian endometrioid adenocarcinoma ovarian serous adenocarcinoma ovarian serous tumor primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOID CARCINOMA OVARY FALLOPIAN TUBE CANCER PRIMARY PERITONEAL CARCINOMA SEROUS OVARIAN TUMOR

Contacts and locations

Locations

Bon Secours

Cork, Munster, Ireland
Cork University Hospital

Cork, Munster, Ireland
Mater Misericordiae University Hospital / Mater Private Hospital

Dublin, Leinster, Ireland
St James's Hospital

Dublin, Leinster, Ireland
University Hospital Limerick

Limerick, Munster, Ireland

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