Cancer Trials Ireland

This early-phase trial tested whether giving a higher radiation dose directly to the lung tumor (while keeping standard doses to surrounding areas) is safe for people with non-small cell lung cancer. Only 6 participants were enrolled before the study was terminated. The goal was …

This study tested whether combining two drugs, trametinib and hydroxychloroquine, could help overcome treatment resistance in people with advanced pancreatic cancer that had spread. The trial aimed to see how many patients were free of cancer growth after 12 weeks. It included 20…

This phase II trial tested two drugs—denosumab and enzalutamide—together in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if the combination could slow cancer growth better than enzalutamide alone. Ho…

This study compared two types of radiation given after breast-conserving surgery for early-stage breast cancer: 3D conformal radiation (external beams) and internal brachytherapy (radioactive material placed in the breast). Only 6 women took part before the trial was stopped earl…

This trial compared two ways of giving pelvic radiotherapy after surgery for endometrial cancer: standard 3D planning versus a newer technique called IMRT. The goal was to see if IMRT could reduce side effects like bladder and bowel problems. The study enrolled 92 participants bu…

This study compared two types of radiation therapy given before surgery for locally advanced rectal cancer. The goal was to see if a newer technique called IMRT causes fewer bowel side effects than the standard 3-D conformal radiotherapy. The trial enrolled 94 patients but was te…