Cancer Trials Ireland

This study tested whether combining two drugs, trametinib and hydroxychloroquine, could help people with advanced pancreatic cancer whose disease had stopped responding to standard treatments. The goal was to see if the combination could slow cancer growth and understand how resi…

This study tested a combination of two drugs, denosumab and enzalutamide, in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if the combination could delay cancer growth longer than historical results w…

This study aimed to compare two radiation methods—3D conformal radiation therapy and internal brachytherapy—given after breast-conserving surgery for early-stage breast cancer. The goal was to see which approach better kills remaining cancer cells while sparing healthy tissue. Ho…

This study tested whether giving a higher dose of radiation to the main tumor could be safe for people with non-small cell lung cancer. It included 6 adults with stage II or III lung cancer who could not have surgery. The trial was ended early, so results are limited.

This study looked at two different ways to give radiation to people with advanced rectal cancer before surgery. The goal was to see if one method (IMRT) caused fewer stomach and bowel side effects than the standard method (3-D conformal radiation). About 94 adults took part, but …

This study looked at 92 women with high-risk endometrial cancer who needed pelvic radiation after surgery. It compared a newer, more precise radiation method (IMRT) with the standard 3D technique to see if it could reduce side effects like bowel and bladder problems. The goal was…