Cancer Trials Ireland

This study tested a combination of two drugs (copanlisib and trastuzumab) in 26 adults with advanced HER2-positive breast cancer that had stopped responding to earlier treatments. The goal was to find the safest dose of copanlisib and see if the combination could shrink tumors or…

This study looked at whether giving a combination of abiraterone acetate, prednisolone, and hormone therapy before radiation can shrink tumors and lower PSA in men with high-risk localized prostate cancer. Forty-five men who had not yet received treatment took these drugs for abo…

This study tested a combination of two drugs, Radium-223 and enzalutamide, in 45 men with advanced prostate cancer that had spread and was no longer responding to hormone therapy. The goal was to see if the combination was safe and tolerable. Researchers tracked side effects and …

This study aimed to find new methods to classify patients with a hard-to-treat form of advanced colorectal cancer. Researchers analyzed tumor samples from 29 adults to identify different subtypes of the disease. The goal was to better understand the cancer, not to test a new trea…

This study looked at whether a special tumor test (called the 21 gene Recurrence Score) changes doctors' decisions about recommending chemotherapy for women with a common type of early breast cancer. 87 patients in Ireland took part. The goal was to see if the test could help avo…

This study looked at 76 adults with advanced colorectal cancer that had spread. They received a combination of chemotherapy (FOLFOX) and a targeted drug called bevacizumab. The main goal was to find biomarkers—biological clues in the blood or tissue—that could predict how well th…

This study looked at whether it's practical to test tumor tissue from ovarian cancer patients for BRCA gene mutations right in the doctor's office. About 200 patients with high-grade ovarian, fallopian tube, or peritoneal cancer took part. The goal was to see if this upfront test…