Cancer Trials Ireland

This study tested a combination of two drugs—denosumab and enzalutamide—in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if the combination could delay cancer growth better than historical results wit…

This study looked at two ways to give radiation to the breast after a lumpectomy for early-stage breast cancer. One method uses a 3D machine to aim radiation from outside, while the other places tiny radioactive tubes inside the breast. The goal was to see which approach works be…

This study tested whether combining two drugs, trametinib and hydroxychloroquine, could help overcome treatment resistance in people with advanced pancreatic cancer that had spread. The trial aimed to see how many patients were free of cancer growth after 12 weeks. It included 20…

This study tested whether giving a higher radiation dose directly to the lung tumor, while keeping standard doses to surrounding areas, is safe for people with non-small cell lung cancer. Six participants received this targeted dose escalation along with chemotherapy. The goal wa…

This study tested whether a newer, more precise radiation method called IMRT could reduce bowel and bladder side effects compared to standard 3D radiation in women who had surgery for high-risk endometrial cancer. About 92 participants were planned. The trial was stopped early, b…

This study compared two radiation methods given before surgery for locally advanced rectal cancer. The goal was to see if intensity modulated radiotherapy (IMRT) causes fewer stomach and bowel side effects than standard 3-D conformal radiotherapy. The study enrolled 94 adults and…