WALDENSTROM MACROGLOBULINEMIA

This early-stage study tests an oral drug called LOXO-338 in people with advanced blood cancers like leukemia, lymphoma, and multiple myeloma. Participants must have already received standard treatments. The main goals are to find the safest dose and see if the drug helps control…

This study tests a combination of two targeted drugs, ibrutinib and venetoclax, in 45 adults with a rare blood cancer called Waldenström macroglobulinemia who have a specific gene mutation (MYD88). The goal is to see if the combo can shrink the cancer significantly. Participants …

This study tests a new drug called sonrotoclax, either alone or combined with another drug (zanubrutinib), in people with Waldenström macroglobulinemia, a slow-growing blood cancer. The goal is to see if the treatment can shrink tumors and control the disease. About 114 adults wi…

This study tests two drugs, pirtobrutinib and venetoclax, in 46 people with Waldenström Macroglobulinemia who have already had at least one prior treatment. The goal is to see if the combination can shrink the cancer more effectively than current options. Participants take both p…

This early-phase trial tests a new drug (PCI-32765) combined with two standard treatments (rituximab and bendamustine) in 48 adults with relapsed non-Hodgkin lymphoma. The goal is to find the safest dose and see how well the combination works. Participants have cancers like folli…

This study tests whether combining acalabrutinib with rituximab is safe and effective for people with nerve damage (neuropathy) linked to two blood conditions: IgM MGUS or Waldenstrom macroglobulinemia. The main goal is to see if the treatment lowers a key protein (IgM) in the bl…

This study tests a drug called loncastuximab tesirine in 21 people with Waldenström macroglobulinemia, a rare blood cancer, whose disease has not responded to at least two prior treatments. The goal is to see if the drug can shrink tumors and lower abnormal protein levels. Partic…

This study tests a combination of two drugs, ixazomib and rituximab, in people with slow-growing B-cell non-Hodgkin lymphoma. The goal is to see how well the drugs shrink or control the cancer. About 33 adults with different types of this lymphoma are taking part.

This study tests whether adding carfilzomib to the standard drug ibrutinib can improve remission rates in people with Waldenström's macroglobulinemia, a rare blood cancer. About 99 participants will receive either the combination or ibrutinib alone. The goal is to see if the comb…

This study tests a chemotherapy-free combination of three drugs (bortezomib, rituximab, and ibrutinib) in 53 people with newly diagnosed Waldenström's macroglobulinemia, a rare blood cancer. The goal is to see if this approach can keep the disease from getting worse for at least …

This study tests an experimental drug called iopofosine I 131 in people with certain blood cancers (like Waldenstrom macroglobulinemia, multiple myeloma, and lymphomas) that have come back or not responded to standard treatments. The drug delivers radiation directly to cancer cel…

This study tests a new drug called nemtabrutinib (formerly ARQ 531) in about 190 people with certain blood cancers (like lymphoma or leukemia) that have come back or not responded to prior therapy. The goal is to see if the drug is safe and can shrink or control the cancer. Parti…

This study tests a modified plan to prevent and treat cytomegalovirus (CMV) infection in people with blood cancers who have had a donor stem cell transplant. CMV is a common virus that can cause serious problems after transplant. The study involves 153 participants and looks at w…

This early-phase study tests an experimental therapy called NKX019 for people with certain blood cancers (like lymphoma and leukemia) that have come back or not responded to other treatments. NKX019 uses donor immune cells (natural killer cells) that are specially designed to fin…

This study tests whether adding a drug called cyclophosphamide after a stem cell transplant can reduce the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The trial includes 35 adults with various blood cancers or seve…

This study tests whether adding the targeted drug acalabrutinib to standard chemotherapy (bendamustine and rituximab) improves outcomes for people with untreated Waldenstrom's macroglobulinemia, a rare blood cancer. About 63 adults will receive the combination for up to a year. T…

This study looks at people and families who may have a higher chance of developing blood or lymph node cancers, like leukemia or lymphoma. Researchers want to learn about the genes, environment, and other factors that raise this risk. Participants fill out health questionnaires, …