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New drug cocktail aims to control rare blood cancer without chemo

NCT ID NCT03620903

Ongoing Disease control Sponsor: Christian Buske Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a chemotherapy-free combination of three drugs (bortezomib, rituximab, and ibrutinib) in 53 people with newly diagnosed Waldenström's macroglobulinemia, a rare blood cancer. The goal is to see if this approach can keep the disease from getting worse for at least one year while being gentle on patients, who are often older. The treatment targets cancer cells directly without traditional chemo side effects.

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Conditions

The condition(s) this trial relates to.

Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WALDENSTROM MACROGLOBULINEMIA

Contacts and locations

Locations

  • 'Alexandra' General Hospital of Athens

    Athens, 11528, Greece

  • DIAKO Ev. Diakonie-Krankenhaus gGmbH, Med. Klinik II

    Bremen, 28239, Germany

  • Gemeinschaftspraxis Dres. Rudolf Schlag, Björn Schöttker, Joachim Haas

    Würzburg, 97080, Germany

  • Hämato-Onkologische Gemeinschaftspraxis Pasing-Fürstenfeldbruck

    München, 81241, Germany

  • Kliniken Maria Hilf GmbH (Krankenhaus St. Franziskus), Medizinische Klinik I (Klinik f. Hämatologie, Onkologie, Gastroentereologie)

    Mönchengladbach, 41063, Germany

  • Kliniken Ostalb Stauferklinikum Schwäbisch Gmünd, Zentrum für Innere Medizin

    Mutlangen, 73557, Germany

  • Klinikum der Universität München, Medizinische Klinik und Poliklinik III

    München, 83177, Germany

  • Studiengesellschaft Onkologie Bielefeld GbR

    Bielefeld, 33604, Germany

  • Universitätsklinikum Halle, Klinik für Innere Medizin IV

    Halle, 06120, Germany

  • Universitätsklinikum Münster, Med. Klinik A

    Münster, 48149, Germany

  • Universitätsklinikum Ulm; Klinik für Innere Medizin Innere Medizin III

    Ulm, 89081, Germany

  • Universtätsmedizin Mannheim, III. Medizinische Klinik Studienzentrale im MCC

    Mannheim, 68167, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.