Chemo-Free cocktail shows promise for rare blood cancer

NCT ID NCT03620903

First seen Jan 07, 2026 · Last updated May 23, 2026 · Updated 30 times

Summary

This study tests a chemotherapy-free combination of three drugs (bortezomib, rituximab, and ibrutinib) as a first treatment for people with Waldenström's macroglobulinemia, a rare blood cancer. The goal is to see if this approach can keep the disease from getting worse for at least a year. About 53 participants will receive the treatment, and researchers will track how well it works and what side effects occur.

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Contacts and locations

Locations

  • 'Alexandra' General Hospital of Athens

    Athens, 11528, Greece

  • DIAKO Ev. Diakonie-Krankenhaus gGmbH, Med. Klinik II

    Bremen, 28239, Germany

  • Gemeinschaftspraxis Dres. Rudolf Schlag, Björn Schöttker, Joachim Haas

    Würzburg, 97080, Germany

  • Hämato-Onkologische Gemeinschaftspraxis Pasing-Fürstenfeldbruck

    München, 81241, Germany

  • Kliniken Maria Hilf GmbH (Krankenhaus St. Franziskus), Medizinische Klinik I (Klinik f. Hämatologie, Onkologie, Gastroentereologie)

    Mönchengladbach, 41063, Germany

  • Kliniken Ostalb Stauferklinikum Schwäbisch Gmünd, Zentrum für Innere Medizin

    Mutlangen, 73557, Germany

  • Klinikum der Universität München, Medizinische Klinik und Poliklinik III

    München, 83177, Germany

  • Studiengesellschaft Onkologie Bielefeld GbR

    Bielefeld, 33604, Germany

  • Universitätsklinikum Halle, Klinik für Innere Medizin IV

    Halle, 06120, Germany

  • Universitätsklinikum Münster, Med. Klinik A

    Münster, 48149, Germany

  • Universitätsklinikum Ulm; Klinik für Innere Medizin Innere Medizin III

    Ulm, 89081, Germany

  • Universtätsmedizin Mannheim, III. Medizinische Klinik Studienzentrale im MCC

    Mannheim, 68167, Germany

Conditions

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