URINARY TRACT INFECTIONS

This study tests a new vaccine designed to prevent urinary tract infections (UTIs) caused by E. coli bacteria. It involves 448 adults aged 18-64, with a focus on safety and immune response in all participants, and early effectiveness in women. The vaccine is given as an injection…

This study looks at whether giving antibiotics by mouth (orally) is as safe and effective as giving them through a vein (IV) for adults who come to the emergency room with common infections like pneumonia, urinary tract infections, or skin infections. About 4,000 participants wil…

This study tests two methods to prevent repeat bladder infections in women over 40 who have gone through menopause. One group takes a nightly antibiotic for 6 months, while the other uses a vaginal tablet containing good bacteria and a low-dose hormone. The goal is to see which a…

This study tests a new treatment called LBP-EC01, made from viruses that attack bacteria, for urinary tract infections (UTIs) caused by drug-resistant E. coli. About 318 adults with a history of UTIs will receive either the virus treatment plus an antibiotic, or a placebo plus th…

This study tests whether a simple technique called "double voiding" (urinating twice in a row) can reduce urinary tract infections (UTIs) in kidney transplant recipients. UTIs are common after transplant and can lead to serious complications. The study will follow 438 adults at o…

This study compares a new DNA-based test (PCR) to the standard urine culture for diagnosing urinary tract infections (UTIs) in adults. Participants are randomly assigned to one test group and tracked for up to 21 days. The goal is to see if the faster DNA test leads to quicker tr…

This study looks at whether a DNA-based urine test (called Next Generation Sequencing) can find bacteria that standard urine cultures miss. It involves 100 women with UTI symptoms but low bacteria counts on the usual test. The goal is to see if the DNA test leads to better treatm…

This study is testing whether a 21-day spa program—including mineral water, baths, and exercise—can improve kidney and urinary tract health in 150 adults aged 40 to 70. Participants will receive standard spa care and have their blood, urine, and body composition measured before a…

This study is testing whether a single shot of the antibiotic amikacin can effectively treat uncomplicated bladder infections in women visiting the emergency department. The goal is to offer a quick, one-time treatment instead of the usual 3-7 day course of pills. The study will …

This study tests a prediction model to help doctors decide when antibiotics are truly needed for urinary tract infections (UTIs) in the emergency room. About 47 women discharged from the ER with a UTI diagnosis will be enrolled. The goal is to reduce unnecessary antibiotic use an…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This early-stage study is testing a new drug called JKN2501 in 66 healthy adults in China. The goal is to see if the drug is safe and how the body processes it, not to treat any disease. Participants will receive either the drug or a placebo by IV, and researchers will monitor fo…