Cure My Disease

Don't miss your cure!

 Log in / Sign up

Phage therapy takes on superbug UTIs in new trial

NCT ID NCT05488340

Recruiting now Disease control Sponsor: Locus Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new treatment called LBP-EC01, which uses specially designed viruses (bacteriophages) to attack drug-resistant E. coli bacteria that cause urinary tract infections (UTIs). About 318 adults with a history of UTIs and a current infection will receive either LBP-EC01 plus an antibiotic or a placebo plus the antibiotic. The goal is to see if adding the phages helps clear the infection and symptoms better than the antibiotic alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
LBP-EC01 (a cocktail of viruses that attack bacteria, called bacteriophages) plus an antibiotic (trimethoprim/sulfamethoxazole)
What this could lead to
If it works, this could offer a new treatment option for people with hard-to-treat urinary tract infections caused by drug-resistant E. coli bacteria.
What could go wrong
This is a phase 2 trial, so it's still early. The treatment may not work better than antibiotics alone, and there could be side effects or immune reactions to the phages.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for URINARY TRACT INFECTIONS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

escherichia coli infection urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

URINARY TRACT INFECTIONS

Contacts and locations

Locations

  • Research Site 102

    RECRUITING

    Doral, Florida, 33166, United States

  • Research Site 103

    RECRUITING

    Miami, Florida, 33176, United States

  • Research Site 118

    COMPLETED

    Winston-Salem, North Carolina, 27157, United States

  • Research Site 120

    COMPLETED

    Boston, Massachusetts, 02115, United States

  • Research Site 123

    RECRUITING

    Los Angeles, California, 90027, United States

  • Research Site 125

    COMPLETED

    Montebello, California, 90640, United States

  • Research Site 126

    RECRUITING

    Tustin, California, 92780, United States

  • Research Site 131

    RECRUITING

    Lancaster, California, 93534, United States

  • Research Site 137

    RECRUITING

    San Diego, California, 92037, United States

  • Research Site 138

    COMPLETED

    Fresno, California, 93710, United States

  • Research Site 140

    COMPLETED

    Jensen Beach, Florida, 34957, United States

  • Research Site 145

    RECRUITING

    Raleigh, North Carolina, 27708, United States

  • Research Site 149

    RECRUITING

    Miami, Florida, 33176, United States

  • Research Site 151

    RECRUITING

    Hialeah, Florida, 33013, United States

  • Research Site 152

    RECRUITING

    Murrieta, California, 92563, United States

  • Research Site 153

    RECRUITING

    Ocala, Florida, 34473, United States

  • Research Site 154

    RECRUITING

    St Louis, Missouri, 63141, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.