URINARY BLADDER NEOPLASMS

This study tests whether adding the experimental drug V940 to standard BCG immunotherapy helps people with high-risk non-muscle invasive bladder cancer live longer without their cancer returning or spreading. About 308 adults whose bladder cancer has not invaded the muscle will b…

This study tests a new medicine called MK-3120 for people with high-risk bladder cancer that hasn't spread to the muscle. After standard surgery to remove the tumor, participants receive MK-3120 directly into the bladder. The main goals are to check safety and side effects, and t…

This early-stage study tests a new drug, LOXO-435, in people with advanced solid tumors, especially urinary tract cancers that have a specific change in the FGFR3 gene. The main goals are to find the best dose and check for safety and side effects. About 535 participants will tak…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before bladder removal surgery is safe and effective for people with muscle-invasive bladder cancer. About 150 participants will receive the drug combination, then undergo surgery. The goal…

This study tests whether a combination of two drugs (enfortumab vedotin and pembrolizumab) can control muscle-invasive bladder cancer and allow patients to keep their bladder. About 390 adults whose cancer hasn't spread outside the bladder and who cannot or choose not to have bla…

This early-stage trial tests a drug called sigvotatug vedotin, alone or with other medicines, in people with advanced solid tumors like lung, head and neck, or breast cancer. The main goal is to check safety and find the right dose. About 1,000 participants will join this study t…

This study tests whether adding a new drug called vepugratinib to two standard cancer treatments (enfortumab vedotin and pembrolizumab) helps adults with advanced or spreading bladder cancer that has a specific FGFR3 gene change. About 450 participants will receive either the new…

This study tests a new way to deliver the drug erdafitinib directly into the bladder using a special system called TAR-210. It is for people with bladder cancer that has not spread into the muscle layer or has spread into it. The goal is to find the best dose and see if it is saf…

This study tests a new MRI technique that uses contrast dyes placed directly into the bladder to see how deep a bladder tumor has grown. The goal is to improve cancer staging before surgery, which could help doctors choose the best treatment. About 42 adults with bladder tumors w…

This study compares 3 versus 6 cycles of platinum-based chemotherapy before maintenance treatment with avelumab in 320 people with advanced bladder cancer. The goal is to see if fewer chemotherapy cycles improve quality of life without affecting disease control. Participants rece…

This study looks at whether giving Blad-Care (a gel that coats the bladder) early during BCG therapy can reduce bladder pain, burning, and urgency better than waiting until after BCG is done. About 56 adults with non-muscle-invasive bladder cancer will be randomly assigned to ear…

This study follows 400 people who have urologic cancer surgery with lymph node removal to see how often leg swelling (lymphedema) happens. Researchers use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better understand this…