URINARY BLADDER NEOPLASMS

This study tests two experimental treatments—TAR-200 (a drug placed directly into the bladder) and cetrelimab (an immunotherapy injection)—alone or together in 220 people with high-risk bladder cancer that did not get better after standard BCG therapy. Participants are those who …

This study tests two treatments for people with a certain type of bladder cancer that has grown into the muscle wall. Participants will get either a drug placed directly into the bladder (TAR-200) plus an immunotherapy injection (cetrelimab), or the injection alone, before their …

This early-stage study tests a new treatment called TAR-210 in 5 Japanese patients with a type of bladder cancer that has certain genetic changes (FGFR mutations). The treatment is placed directly into the bladder to deliver the drug erdafitinib. The main goal is to see if it is …

This study tests whether adding the immunotherapy drug nivolumab (with or without another drug) to standard chemotherapy before and after surgery can improve outcomes for people with muscle-invasive bladder cancer. About 855 adults who are eligible for bladder removal surgery wil…

This study tests whether a combination of two drugs (TAR-200 and cetrelimab) can help people with a serious type of bladder cancer avoid having their bladder removed. About 518 participants who cannot or choose not to have bladder removal surgery will receive either the drug comb…

This study tests whether combining two drugs, durvalumab and olaparib, can help people with advanced bladder cancer that has spread and cannot be removed by surgery. Participants are those who cannot receive standard platinum-based chemotherapy. The goal is to see if the combinat…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemoradiotherapy helps people with muscle-invasive bladder cancer live longer without their cancer returning or spreading. About 520 participants will receive either pembrolizumab or a placebo along…

This study looks at whether advanced imaging scans (FAPI PET/MRI, FDG PET/MRI, and MRI) can more accurately diagnose muscle-invasive bladder cancer and predict how well pre-surgery treatment works. About 80 participants will undergo these scans before and after therapy. The goal …

This study looks at whether a urine test called BladMetrix can safely detect bladder cancer coming back after surgery. About 500 adults with non-invasive bladder cancer will provide extra urine samples during their regular check-ups over two years. The goal is to see if the test …