UNRESECTABLE MALIGNANT SOLID NEOPLASM
Clinical trials for UNRESECTABLE MALIGNANT SOLID NEOPLASM explained in plain language.
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New cancer drug combo enters first human safety trial
Disease control Recruiting nowThis early-stage trial aims to find a safe and effective dose of a new drug, ZEN003694, when given with the standard chemotherapy capecitabine. It is for adults with advanced solid tumors (like colorectal cancer) that have spread or cannot be removed by surgery and have worsened …
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Scientists test novel drug duo in fight against Tough-to-Treat cancers
Disease control Recruiting nowThis early-phase study aims to find a safe and tolerable dose of a new drug combination for people with advanced breast cancer and other solid tumors that have a protein called HER2. The trial will test pidnarulex, which aims to stop tumor cell growth, together with an existing t…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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New drug duo aims to halt advanced cancers by targeting their genetic weaknesses
Disease control Recruiting nowThis study is testing whether a combination of two oral drugs, ZEN-3694 and talazoparib, can shrink or stop the growth of advanced solid tumors that have specific genetic features. It aims to enroll 88 adults whose cancer has progressed despite prior treatments. A key goal is to …
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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New hope for tough cancers: experimental drug enters first human testing
Disease control Recruiting nowThis is the first human study of a new chemotherapy drug called TR-002. It aims to find the safest dose and understand side effects for people with advanced solid tumors, including pancreatic cancer, that have stopped responding to standard treatments. The study will enroll 52 pa…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: University of California, Davis • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Major trial uses genetic blueprint to find the right drug combo for advanced cancer
Disease control Recruiting nowThis trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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First human trial tests new drug duo against aggressive cancers
Disease control Recruiting nowThis early-stage study aims to find the safest dose of two oral drugs—ZEN003694 and abemaciclib—when given together to patients with advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 45 adults and teens (12+) with specific cancers, inc…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Scientists test new drug duo to attack tough cancers
Disease control Recruiting nowThis early-stage study is testing a new combination of two drugs, DS-8201a and olaparib, for people with advanced cancers that have a protein called HER2. The main goal is to find the safest and most effective dose. Researchers will also check if the treatment helps shrink or con…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Scientists test 'One-Two Punch' against Tough-to-Treat cancers
Disease control Recruiting nowThis early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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Early trial tests old antibiotic as new weapon against tough cancers
Disease control Recruiting nowThis is an early safety study testing a drug called novobiocin in people with advanced solid tumors that have specific mutations affecting DNA repair. The main goal is to find the safest dose and understand the side effects. Researchers hope the drug will block a cancer cell's ba…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Scientists test 'Double Punch' drug combo for Tough-to-Treat stomach cancers
Disease control Recruiting nowThis early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced cancers that have a specific marker called HER2. The trial focuses on stomach and gastroesophageal junction cancers that have spread or cannot be removed by surgery, …
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Custom-Made vaccine aims to train immune system to fight advanced cancers
Disease control Recruiting nowThis study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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Scientists test novel drug duo to halt advanced cancers
Disease control Recruiting nowThis early-stage trial is testing a new combination of two oral drugs, peposertib and tuvusertib, in adults with advanced solid tumors that have spread and stopped responding to standard treatments. The main goals are to find the safest and most effective dose of the drug pair an…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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New cancer pill targets tumor growth enzyme in first human trial
Disease control Recruiting nowThis is the first study in people testing a new oral drug called MTI-301 for advanced solid cancers that have spread or cannot be removed by surgery. The main goal is to find the highest safe dose and understand the drug's side effects in 42 patients whose cancers have not respon…
Matched conditions: UNRESECTABLE MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 09, 2026 14:26 UTC