ULCERATIVE COLITIS (UC)

This study compares a new strategy using stool tests to guide treatment against standard care for people with ulcerative colitis (UC) who are in remission. About 240 adults with stable UC will be randomly assigned to either have their treatment adjusted based on stool biomarker l…

This study tests a new drug called SSGJ-627 in 288 adults with moderate to severe ulcerative colitis (UC). The goal is to see if it safely reduces symptoms like bleeding and diarrhea. Participants must have tried other treatments without success. This is a phase 2 trial, so it's …

This early-phase study tests a new drug, cizutamig, in 15 adults with moderate to severe ulcerative colitis who have not responded to other treatments. The main goal is to check if the drug is safe and tolerable. Researchers will monitor side effects and how the body reacts to th…

This study tests whether a daily synbiotic formula (SGR11) can improve symptoms and quality of life in 50 adults with mild-to-moderate ulcerative colitis, a type of inflammatory bowel disease. Participants take the formula for 8 weeks and complete questionnaires and stool tests t…

This early-stage study tests a new cell therapy called CNK-UT009 in 40 people with severe inflammatory bowel disease (Crohn's or colitis) that hasn't improved with standard treatments. The main goal is to check safety and find the best dose, while also looking at how well it work…

This study tests whether the antibiotic vancomycin can safely improve symptoms of ulcerative colitis in people who also have a liver condition called primary sclerosing cholangitis. Fourteen adults will take vancomycin or a placebo for 4 weeks to see if it helps. The main goal is…

This pilot study will enroll 25 adults with moderate-to-severe ulcerative colitis who are starting a new treatment. Researchers will compare a modified ultrasound technique to standard endoscopy to see if it can accurately measure disease activity and severity. If successful, thi…

This study looks at whether taking 2,000 IU of vitamin D daily for a year can improve health and disease activity in people with Crohn's disease or ulcerative colitis. Researchers will track how well participants stick to the supplement routine and measure changes in quality of l…

This study tests a new imaging method to see if two common IBD drugs (adalimumab and risankizumab) actually reach the inflamed gut tissue. About 30 adults with ulcerative colitis or Crohn's disease will receive a tiny dose of fluorescent versions of these drugs before a routine c…

This study aims to develop digital biomarkers that can detect disease activity in people with Crohn's disease or ulcerative colitis. Researchers will monitor 80 adults using passive data from smartwatches and grocery shopping habits. The goal is to see if these everyday signals c…

This study looks at why fecal transplants succeed or fail in treating recurrent C. diff, ulcerative colitis, and metabolic syndrome. Researchers will track gut bacteria, viruses, fungi, immune cells, and metabolites in 90 adults over time. The goal is to find patterns that predic…