TYPE2DIABETES

This study tests whether a supplement called NMN, which boosts a natural cell compound called NAD, can improve kidney health in people with type 2 diabetes and diabetic kidney disease. About 156 adults will take either NMN or a placebo twice daily for 6 months. The main goal is t…

This study compares two common diabetes medications—SGLT2 inhibitors and GLP-1 receptor agonists—to see which is better at preventing heart attacks, strokes, kidney failure, and death in people with type 2 diabetes who also have or are at high risk for heart disease. About 6,000 …

This study tests whether a series of plant-based nutrition classes can improve health and lower healthcare costs for 700 Blue Cross Blue Shield subscribers with type 2 diabetes. Participants will follow a plant-based diet for 16 weeks and attend weekly online classes. The study m…

This study tests a 6-month program combining exercise training, problem-solving skills, and community health worker support for 210 adults with type 2 diabetes, obesity, and early signs of heart trouble. Participants must have low income and live in Baltimore or Washington County…

This study looks at whether giving free fruits and vegetables to adults at risk for Type 2 Diabetes helps them stick with a diabetes prevention program and lower their blood sugar. About 100 adults with prediabetes or high blood sugar will take part. Researchers will track how ma…

This study tests if a type of therapy called Dialectical Behavioral Therapy (DBT) can help teens aged 14-17 who are at risk for type 2 diabetes. The therapy focuses on managing emotions and building healthy habits. Participants will be placed in one of three groups: lifestyle cha…

This study looks at whether a 6-week program of non-weight bearing exercise can speed up healing of diabetic foot ulcers compared to standard wound care alone. About 40 adults with Type 2 diabetes and a foot ulcer will be randomly assigned to either exercise plus standard care or…

This study helps older adults with type 2 diabetes who take sulfonylurea drugs—which can cause dangerous low blood sugar and heart problems—switch to newer, safer medications. Researchers will give some patients a simple question sheet to start a conversation with their doctor, w…

This study tests whether taking vitamin B1 (thiamine) capsules can improve brain function and repair the blood-brain barrier in adults with type 2 diabetes. About 52 participants will have MRI scans, memory tests, and blood work over two visits, three months apart. The goal is to…

This study is testing whether a 12-week home-based strength training program, supported by video calls, is practical and helpful for adults aged 55-80 with type 2 diabetes and mild cognitive impairment. Researchers will track how many people finish the program and how often they …

This study looks at whether giving doctors a detailed geriatric assessment (including frailty and overall health) helps them choose safer and more effective diabetes treatments for patients aged 60 and older. About 220 participants will be randomly assigned to usual care or to ha…

This study looks at why diabetes can damage the heart even without clogged arteries. Researchers will examine heart tissue and use advanced imaging in 500 adults with heart failure, with or without type 2 diabetes. The goal is to understand how heart cells' energy factories (mito…

This study looks at how SGLT2 inhibitors, a type of diabetes medicine, change energy levels in the heart and muscles. Researchers will measure key energy molecules in 71 adults with type 2 diabetes and heart failure. The goal is to understand how these drugs work, not to test a n…

This study looks at how cutting calories affects the way the liver processes amino acids, sugars, and fats in people with type 2 diabetes. Researchers want to see if weight loss helps the liver respond better to a hormone called glucagon. About 20 adults with type 2 diabetes and …

This study tests whether doing a diabetes test right after giving birth (before leaving the hospital) is better than waiting 4-12 weeks, as is standard. It also asks women about their views on heart health programs after pregnancy. About 104 women who had gestational diabetes wil…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health problems like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease…