SUBARACHNOID HEMORRHAGE, ANEURYSMAL

This study tests whether giving the drug milrinone directly into the brain's arteries, followed by a 72-hour IV drip, can prevent brain damage in people who develop artery spasms after a bleeding stroke from a burst aneurysm. The trial will enroll 306 adults across multiple hospi…

This study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…

This study tests a simple, non-invasive treatment called remote ischemic conditioning (RIC) for people who have had a brain bleed from a burst aneurysm. The treatment involves briefly inflating a blood pressure cuff on a limb to improve blood flow and reduce brain damage. Researc…

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after surgery for a ruptured brain aneurysm. RIC involves using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions, which may trigg…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study tests whether a nerve block injection near the cheek can relieve severe headaches after a brain bleed (subarachnoid hemorrhage). The injection contains a numbing medicine and a steroid. The goal is to see if it reduces the need for opioid painkillers. About 195 adults …

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study tracks 500 adults in Canada and the US who have had a brain aneurysm bleed and are taking the drug nimodipine. Researchers will measure how much of the drug gets into each patient's blood and see how that relates to their recovery 90 days later. The goal is to understa…

This study looks at how much of the antibiotic telavancin gets into the brain fluid of 20 critically ill patients who have a drain in their head (external ventricular drain). These patients often need strong antibiotics, but it's not clear if telavancin reaches the brain well eno…

This study examines whether memory problems after a type of brain bleed (aneurysmal subarachnoid hemorrhage) are linked to a smaller hippocampus, a brain area key for memory. Researchers will compare 30 patients in rehabilitation with healthy volunteers using memory tests and MRI…