STAGE IV OVARIAN CANCER AJCC V8

This early-stage study is testing a new combination treatment for gynecologic cancers that have returned after previous therapy. Researchers are combining an oral drug called talazoparib with standard radiation therapy to see if it works better together. The main goal is to find …

This early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…

This study is testing if a new drug called PLX038 can shrink tumors in people with advanced ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to standard platinum-based chemotherapy. The drug works by blocking enzymes that cancer cells need to grow…

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific mutations in genes that help repair DNA damage. It is enrolling 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, an…

This early-stage study is testing the safety of a new, minimally invasive procedure called PIPAC. It delivers chemotherapy as a fine mist directly into the abdomen for people with advanced ovarian, uterine, stomach, colon, or appendix cancers that have spread to the abdominal lin…

This is a first-in-human study to find a safe dose of a new oral drug called IACS-6274. It will be tested alone and in two different drug combinations in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check the safety …

This early safety study is testing whether delivering heated chemotherapy directly into the abdomen during surgery is safe for patients with advanced ovarian, fallopian tube, or peritoneal cancer. The trial compares two approaches: giving standard chemotherapy the day before surg…

This study is testing whether a personalized exercise program, guided by a Fitbit, helps patients with ovarian or endometrial cancer meet the recommended 150 minutes of weekly activity better than standard advice. It aims to see if more exercise improves quality of life, physical…

This large study is testing whether a less invasive 'keyhole' surgery works as well as traditional open surgery for women with advanced ovarian, fallopian tube, or primary peritoneal cancer. All participants receive chemotherapy before surgery. Researchers want to see if the mini…

This study is testing whether taking probiotic supplements during chemotherapy can help improve gut and vaginal bacteria health in women with advanced or recurrent ovarian cancer. Researchers want to see if these supplements can reduce side effects, improve quality of life, and p…

This study is developing a new test to detect ovarian cancer at an earlier, more treatable stage. Researchers will collect a uterine wash fluid sample and a blood sample from 250 women before they have surgery. They will analyze these samples to see if specific genetic and protei…

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…