STAGE IV LUNG CANCER AJCC V8
Clinical trials for STAGE IV LUNG CANCER AJCC V8 explained in plain language.
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New combo therapy targets hard-to-treat lung cancer mutation
Disease control Not yet recruitingThis study tests whether adding a cancer vaccine (CIMAVAX-EGF) to standard targeted drugs (sotorasib or adagrasib) can help control advanced lung cancer with a KRAS G12C mutation. About 29 adults with stage III or IV non-small cell lung cancer will receive the combination. The go…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Jun 16, 2026 12:50 UTC
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New radiation drug targets bone tumors while sparing marrow
Disease control Not yet recruitingThis early-phase trial tests a new form of tin-based radiation drug (Sn-117m-DTPA) designed to target cancer that has spread to the bones from prostate, breast, or lung cancer. The drug delivers low-level radiation directly to bone tumors while being gentler on the bone marrow. T…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 15, 2026 19:09 UTC
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New hope for hard-to-treat lung cancer: drug duo aims to reignite immune attack
Disease control Not yet recruitingThis study tests a combination of two drugs, SX-682 and atezolizumab, in people with advanced non-small cell lung cancer whose disease worsened after chemotherapy and immunotherapy. The goal is to see if this new pair can shrink tumors or slow cancer growth. About 32 adults will …
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Disease control
Last updated Jun 15, 2026 18:57 UTC
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Could a cheaper, Lower-Dose immunotherapy work just as well for advanced cancers?
Disease control Not yet recruitingThis study tests whether giving a lower dose of the immunotherapy drug nivolumab less often can still control advanced cancers that have spread or cannot be removed. About 50 adults with various cancers (like melanoma, lung, or kidney cancer) will receive the treatment. The goal …
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 15, 2026 18:56 UTC
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New drug combo aims to shrink Hard-to-Treat lung tumors
Disease control Not yet recruitingThis study tests two drugs, sacituzumab govitecan and ivonescimab, alone or together, in people with advanced non-small cell lung cancer that has specific gene changes. The goal is to see if the combination works better than either drug alone at shrinking tumors and delaying canc…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jun 15, 2026 18:55 UTC
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Light and immune combo takes on hard-to-treat lung cancer
Disease control Not yet recruitingThis study tests a new treatment for people with advanced non-small cell lung cancer that has stopped responding to standard therapies. The treatment combines a light-activated drug (ASP-1929) with an immunotherapy drug (cemiplimab) to target and kill cancer cells. About 27 adult…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Jun 11, 2026 12:11 UTC
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New PET tracer could spot which lung tumors are still growing
Diagnosis Not yet recruitingThis early-phase study is testing a new imaging agent called 64Cu-DOTA-pembrolizumab to see if it can safely show which tumors are still growing in people with stage IV non-small cell lung cancer who are already on the immunotherapy drug pembrolizumab. Six participants will get a…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Diagnosis
Last updated Jun 16, 2026 12:49 UTC
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Spinal tap could spot brain metastases early in lung cancer patients
Knowledge-focused Not yet recruitingThis study tests whether a lumbar puncture (spinal tap) can find tumor DNA in the fluid around the brain and spine of people with stage III or IV non-small cell lung cancer. The goal is to see if this test can help predict which patients will develop brain metastases. About 40 pa…
Matched conditions: STAGE IV LUNG CANCER AJCC V8
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:52 UTC