STAGE III BREAST CANCER AJCC V7

This study tests two hormone therapies, tamoxifen and a newer drug called z-endoxifen, in postmenopausal women with a type of advanced breast cancer (ER+/HER2-). The goal is to see which one better delays cancer growth. About 81 women who have already tried an aromatase inhibitor…

This phase 3 trial tests whether adding the immunotherapy drug pembrolizumab after standard chemotherapy helps prevent triple-negative breast cancer from returning. About 1,155 patients with residual cancer after chemo are randomly assigned to receive pembrolizumab or a placebo. …

This early-phase trial tests the safety and best doses of two drugs (bevacizumab and temsirolimus) given alone or with other medicines (valproic acid or cetuximab) in people with advanced cancer or certain non-cancerous diseases that are hard to treat. The goal is to find the hig…

This study tests the drug pembrolizumab in 21 adults with advanced solid tumors that have specific gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or control the cancer. Pembrolizumab is a type of immunotherapy that helps the immune system…

This study tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy before surgery helps shrink tumors more than chemo alone in people with stage II-III triple negative breast cancer. About 67 participants received either chemo alone or chemo plus atezol…

This early-stage trial tests a gel form of the drug endoxifen on women scheduled for breast surgery. The goal is to find the safest dose and see if it can treat or lower the risk of breast cancer. About 32 women with various stages of breast cancer or high risk will apply the gel…

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced or inoperable solid tumors, including certain breast, lung, and pancreatic cancers. The goal is to see if the combo can shrink tumors or slow their growth by blocking enzymes that cancer …

This study looks at whether an integrative oncology program—including diet advice, physical activity, stress management, social support, and reducing exposure to environmental toxins—can improve outcomes for women with stage II or III breast cancer undergoing radiation therapy. A…

This study tests if a special type of acupuncture (electroacupuncture) can reduce chronic pain in women who have finished treatment for early-stage breast cancer. About 111 women with persistent pain for at least 3 months after surgery will receive either real acupuncture, a sham…