SENSORINEURAL HEARING LOSS, BILATERAL

This trial tests a gene therapy called AAVAnc80-hOTOF for people with severe hearing loss caused by mutations in the otoferlin gene. The therapy is given as a single injection into the inner ear during surgery. The study will check if the treatment is safe and if it can improve h…

This study compares two ways of tuning cochlear implants to see which helps adults with hearing loss understand speech better, especially in noisy settings. About 25 French-speaking adults who have had a cochlear implant for six months will try both settings. The goal is to find …

This study compares two methods for tuning cochlear implants: a standard tonotopic-based setting (FS4T) and a new setting adjusted by an evolutionary algorithm (EAFS4T). Researchers want to see which one helps 22 adults with hearing loss understand speech better, especially in no…

This study compares two ways of tuning cochlear implants for people who also use a hearing aid in the other ear. The new method aims to match the implant's sound processing to the natural pitch map of the ear. Twenty adults with hearing loss will try both tuning methods to see wh…

This study compares two fitting methods for people who use a cochlear implant in one ear and a hearing aid in the other. One method synchronizes the devices, the other does not. Researchers want to see if synchronization helps with sound localization and speech understanding in n…

This study looks at whether stimulating deeper parts of the inner ear with a cochlear implant helps people hear music better. About 32 adults with hearing loss who already qualify for a cochlear implant will test two different stimulation depths. The goal is to see if the deeper …

This study follows 180 children up to age 16 who have hearing loss caused by mutations in the GJB2 or OTOF genes. Researchers will regularly measure their hearing using standard tests and questionnaires to see how it changes over time. The goal is to better understand the natural…

This study looks at adults aged 30 to 55 who have hearing loss that started after age 16 and carry a mutation in the GJB2 gene. Researchers will track how their hearing changes over time using hearing tests and genetic analysis. The goal is to better understand this form of heari…

This study follows up to 150 people with hearing loss caused by changes in the otoferlin gene. Researchers will measure hearing function using tests like auditory brainstem response (ABR) and otoacoustic emissions (OAE). The goal is to learn how this type of hearing loss changes …