SAFETY ISSUES

This early-stage study tested an oral drug called ICM20 in 13 adults with Chagas disease who had not been treated before. The main goal was to check for side effects and see how well the drug was tolerated over 60 days. Researchers also tracked how many participants stayed on the…

This early-stage study tested a vaginal insert containing two anti-HIV drugs (tenofovir alafenamide and elvitegravir) in 68 healthy women. The goal was to see if the insert is safe and how much drug gets into vaginal fluids and blood. The insert is designed for on-demand use befo…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement is safe. About 2904 adults took part. Researchers tracked serious problems like heart attack, stroke, bleeding, or kidney failure for 90 days after surgery.

This study tested whether wearing a special facemask during upper endoscopy (a scope procedure for the stomach and gut) lowers the amount of tiny particles released into the air. Fifty-seven adults having elective upper endoscopy were randomly assigned to either wear a facemask o…

This study tested a lean leadership training program for head nurses at Mansoura Children Hospital. The goal was to see if the training could improve head nurses' performance and make the workplace safer for staff nurses. About 200 nurses took part, and the researchers measured s…

This early-stage study tested a vaginal ring that slowly releases two medicines (dapivirine and levonorgestrel) over 90 days to prevent HIV and pregnancy. Forty healthy HIV-negative women used the ring to check how much drug gets into the body and if it causes any side effects or…

This study tested whether a cell-free fat tissue product is safe to inject under the skin. 38 healthy adults received the product on one arm and a saltwater solution on the other. Researchers monitored for side effects like swelling, pain, or allergic reactions. The goal was only…