SAFETY ISSUES

This early-phase trial tested the safety of an experimental drug called ICM20 in 13 adults with Chagas disease who had not been treated before. Participants took ICM20 along with the standard drug benznidazole. The main goal was to check for side effects and see how many people s…

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleedi…

This early-stage trial tested a vaginal insert containing two anti-HIV drugs (tenofovir alafenamide and elvitegravir) in 68 healthy women. The insert was used daily for 3 days then every other day for 14 days. The goal was to check safety and measure drug levels in the body, as a…

This study tested a vaginal ring that slowly releases two medicines: dapivirine (to prevent HIV) and levonorgestrel (a contraceptive). Forty healthy women without HIV used the ring for 90 days. Researchers measured drug levels in blood and vaginal fluid and checked for side effec…

This study tested whether a new cell-free fat tissue product, called Liponovo, is safe to inject into the skin. 38 healthy adults received an injection of the product in one arm and a plain saltwater solution in the other. Researchers monitored for side effects like redness, swel…

This study looked at whether wearing a special facemask during upper endoscopy (a procedure to examine the stomach and esophagus) can reduce the spread of tiny particles into the air. The goal was to better understand infection risks, like COVID-19, for healthcare workers. Resear…

This study tested a lean leadership training program for head nurses at Mansoura Children Hospital. The goal was to see if the training could improve head nurses' performance and make the workplace safer for staff nurses. About 200 head nurses and staff nurses took part, and the …