SAFETY

This study tested if injecting the antifungal drug fluconazole directly into the cornea is safe and effective for treating fungal keratitis, a serious eye infection. 40 patients with lab-confirmed fungal infections that were sensitive to fluconazole took part. The researchers mea…

This trial tested a new treatment called GC101 TIL for people with advanced melanoma that has not responded to standard therapies. The treatment uses immune cells taken from the patient's own tumor, grown in a lab, and then given back to the patient. The study enrolled 18 partici…

This early-phase trial tested a personalized immunotherapy for people with advanced solid tumors. Doctors removed a sample of each patient's tumor, grew the immune cells (TILs) in a lab, and then infused them back along with another drug. The goal was to see if this approach is s…

This study tested a new daily supplement called KGA-10 (a heat-killed bacterium) in 107 healthy adults to see if it could lower stress, reduce inflammation, and improve sleep and general well-being. Participants took either the supplement or a placebo for 8 weeks and completed su…

This study tested a numbing injection given around both eyes to see if it safely controls pain during cataract surgery. Fifty adults received the injection, and researchers measured their pain and satisfaction. The goal was to find a better way to keep patients comfortable during…

This study looked at whether taking a dietary supplement for 60 days could improve thinking skills and mood in 75 university students. Participants were split into three groups: two received different supplements, and one got a placebo. Researchers measured changes in self-confid…

This completed study tested whether an oral probiotic called Streptococcus salivarius eK12 is safe and well-tolerated in healthy adults. Researchers gave 29 participants either the probiotic or a placebo and monitored for side effects, changes in vital signs, and blood test resul…

This completed trial tested whether a heat-killed bacterium called KGA-10 (also known as NeuroAlly) is safe and tolerable for healthy adults. Eight participants took either KGA-10 or a placebo daily for one week. Researchers tracked side effects and satisfaction using surveys. Th…

This completed trial tested an online tool called 'Safety in Dementia' that guides caregivers through decisions about firearm access for a person with dementia. 500 informal caregivers across the U.S. participated. The tool helps clarify options, risks, and personal values, aimin…

This study tested a new way to teach personal safety to 60 children aged 4-5. Half of the kids took part in a special program using games and activities based on multiple intelligences theory, while the other half had regular lessons. The program aimed to improve children's knowl…

This study tested a new micellar form of the antioxidant glutathione in 16 healthy adults. Researchers compared how well it was absorbed versus standard and liposomal glutathione capsules over 30 days. The goal was to see if the new formulation leads to higher levels in the blood…

This study tested a community bike safety program for 195 kids ages 9 to 12. Some kids took a 12-hour safety class, some took the class plus a parent training session, and others received no training. All bikes were equipped with GPS and video cameras to track real-world riding b…

This study tested whether giving the drug pasireotide with a reusable pen works as well as using a traditional syringe. Forty healthy adults received a single dose by both methods to compare how the drug enters the body and if it is safe. The goal is to find a more convenient way…

This study looked at whether it is safe for pregnant women to receive the mRNA COVID-19 vaccine and the flu shot at the same time versus a few weeks apart. 98 pregnant women were randomly assigned to one of the two schedules. Researchers tracked side effects, pregnancy outcomes, …

This early-stage study tested whether a purified exosome product (PEP) is safe when injected into the skin of healthy adults. Eight participants received the injection and were monitored for side effects. The goal was to check for any immediate reactions or lab changes, not to tr…

This early-stage study tested a single dose of the experimental drug Y-3 in 20 healthy adults to see if it is safe and how the body processes it. Participants received either 40 mg, 60 mg, or a placebo. The study is complete and focused on gathering basic safety and drug-level in…

This completed study tested single doses of kratom in 40 healthy adults who have used opioids recreationally. Researchers measured safety, side effects, and how the body processes kratom. The goal was to gather basic information, not to treat any condition.