PROSTHETIC JOINT INFECTION

This study tests if a new drug called PLG0206 can stop infections from coming back in people who have had a knee replacement and need surgery to treat an infection. About 240 adults will get either PLG0206 or a placebo during their surgery, along with standard care. Researchers w…

This study tests if a special gel, Prontosan, applied to the skin during shoulder replacement surgery, can reduce bacteria that might cause infections. It involves 60 men having shoulder replacement. Researchers will compare bacteria growth in those who get the gel versus those w…

This study tests whether taking probiotics alongside standard treatment can improve immune markers and recovery in people with hip or knee joint infections. About 152 adults aged 18-90 who are scheduled for surgery and antibiotics will be enrolled. Researchers will measure inflam…

This study looks at two different surgeries for people with an infected artificial knee joint. One approach uses a temporary antibiotic spacer and requires a second surgery later. The other uses a new artificial knee with antibiotic cement in a single surgery. Researchers want to…

This study looks at whether combining blood and joint fluid tests can more accurately detect infections in people who need a second hip or knee replacement surgery. Researchers will compare these tests to standard methods in 270 patients. The goal is to find the best, most cost-e…

This study looks back at the medical records of 150 patients who died in intensive care units between 2018 and 2022 after being treated for a joint prosthesis infection. Researchers want to understand what these patients had in common, how they were treated, and what led to their…

This study looks at how much fluid surgeons need to use to fully clean an infected artificial knee joint during a special surgery called DAIR. About 20 adults with knee replacements and infections will take part. Doctors will use a blue dye to track contamination and take photos …

This study follows 50 adults with infected hip replacements to see how well different treatments work over time. Researchers will track infection clearance, complications, and treatment choices. The goal is to improve patient counseling and care quality, not to test a new drug or…