POSTPARTUM HEMORRHAGE

This study tests a device called KOKO, which uses gentle suction inside the uterus to remove excess blood and help the uterus contract, stopping heavy bleeding after childbirth. About 72 women who experience significant blood loss within 24 hours of delivery will be enrolled. The…

This study tests whether giving a clotting protein called factor XIII early can reduce blood loss in women with heavy bleeding after childbirth. About 988 women having a vaginal delivery will be randomly assigned to receive either factor XIII plus standard care or standard care a…

This trial tests a quality improvement program called 'Rule of THUMB' in African hospitals. The program uses checklists to help doctors assess bleeding risk before, during, and after C-sections, and to ensure proven treatments are given quickly. About 2,400 patients will take par…

This study tests different doses of oxytocin, a drug that helps the uterus contract after childbirth, to find the lowest effective dose for women having a C-section after labor. The goal is to prevent postpartum hemorrhage (heavy bleeding) while minimizing side effects. Forty wom…

This study looks at whether draining the umbilical cord after delivery can lower the chance of severe bleeding (postpartum hemorrhage) in new mothers. About 400 women having a vaginal birth will be randomly assigned to either have cord drainage or not. Researchers will measure bl…

This study tests a simple technique: after cutting the umbilical cord, doctors open the clamp to let blood drain from the placenta. The goal is to see if this speeds up delivery of the placenta and reduces bleeding after birth. About 80 low-risk pregnant women will take part. The…

This study tests a non-invasive device called the AAJT-S, which is placed over the upper belly and inflated to temporarily stop blood flow to the pelvis. It is being used for 20 women with severe postpartum hemorrhage that does not respond to standard treatments like medication o…

This study tests if carbetocin, a drug that helps the uterus contract, works better than standard oxytocin to prevent heavy bleeding after twin deliveries. Heavy bleeding is more common with twins and can cause serious health problems. About 120 pregnant people with twins will be…

This study uses small samples of uterine tissue from 32 women having planned C-sections to test which backup drug best contracts the uterus after carbetocin has been given. The goal is to improve treatment for severe bleeding after childbirth. The research is done in the lab, not…

This study looks at how three common blood pressure medications (ephedrine, phenylepinephrine, and norepinephrine) affect the ability of the uterus to contract after a C-section in women with type 2 or gestational diabetes. Researchers will take small tissue samples from the uter…

This study looks back at medical records of 648 women who had heavy bleeding after a C-section. Researchers want to see how often the drug tranexamic acid (TXA) was given over the years, and whether more use led to better outcomes like less blood loss or fewer transfusions. The g…

This study tests whether a serious game can improve nursing students' knowledge and confidence in managing postpartum hemorrhage (severe bleeding after childbirth). Seventy third-year nursing students will be split into two groups: one gets traditional training plus the game, the…