OSTEOARTHRITIS (OA) OF THE KNEE
Clinical trials for OSTEOARTHRITIS (OA) OF THE KNEE explained in plain language.
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Could a simple knee injection ease arthritis pain?
Disease control OngoingThis study tests whether a protein called TPX-100, injected into the knee, can safely reduce pain and improve function in people with mild to severe knee osteoarthritis. About 270 adults aged 50 to 80 will receive either the drug or a placebo once a week for four weeks, then be f…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: PHASE2 • Sponsor: OrthoTrophix, Inc • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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New drug could replace opioids for knee surgery pain
Symptom relief ENROLLING_BY_INVITATIONThis study tests whether a new drug called suzetrigine can control pain after knee replacement surgery as well as oxycodone, a common opioid. About 140 adults with knee osteoarthritis will receive either suzetrigine or oxycodone for two weeks after surgery. Researchers will track…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: PHASE4 • Sponsor: University of Louisville • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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One-Shot gene therapy could ease knee arthritis pain for years
Symptom relief OngoingThis Phase 2 trial tests a single injection of a gene therapy called PCRX-201 in 135 adults aged 45–80 with painful knee osteoarthritis. Participants receive one of two doses or a placebo, then are monitored for safety and pain relief over 5 years. The goal is to see if the injec…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: PHASE2 • Sponsor: Pacira Pharmaceuticals, Inc • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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New knee brace and simple exercise method could ease arthritis pain
Symptom relief ENROLLING_BY_INVITATIONThis study tests a new knee brace designed to reduce joint pressure and a special low-intensity exercise method (blood flow restriction training) to strengthen leg muscles. Researchers will compare the new brace to a traditional one in 40 volunteers over 50 with knee osteoarthrit…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: China Medical University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Freeze your knee pain away? new cold injection trial aims to ease arthritis
Symptom relief OngoingThis study tests a new injectable treatment called Neural Ice that uses cold energy to reduce chronic knee pain from osteoarthritis. About 263 adults aged 22 to 80 with moderate to severe pain will receive the injection and be monitored for 6 months. The goal is to see if it prov…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: Brixton Biosciences, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 07:55 UTC
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Does an extra knee ligament procedure lead to arthritis later?
Knowledge-focused ENROLLING_BY_INVITATIONThis study follows 510 people who had ACL knee reconstruction surgery, with or without an extra procedure called LET, about 10 years ago. Researchers want to see if adding LET increases the chance of developing knee osteoarthritis. Participants will get X-rays and answer question…
Matched conditions: OSTEOARTHRITIS (OA) OF THE KNEE
Phase: NA • Sponsor: Western University, Canada • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC