OSTEOARTHRITIS (OA) OF THE KNEE

This early-phase trial tests whether the weight-loss drug semaglutide can improve outcomes for obese patients waiting for total knee replacement. 54 participants will receive the drug for 48 weeks before and after surgery. The goal is to see if weight loss reduces pain and compli…

This study looks at ways to reduce pain during knee steroid injections for osteoarthritis. Researchers will test if using a thinner needle or a numbing spray (ethyl chloride) makes the injection hurt less. 88 adults with knee osteoarthritis will rate their pain right after the sh…

This study tests whether walking backwards on a treadmill (called retro walking) can help reduce pain and improve how people with knee osteoarthritis walk. Participants will do retro walking sessions, starting with 10 minutes and gradually increasing up to 30 minutes if pain stay…

This study will test Mobithron Xtra, an oral supplement containing hyaluronic acid, collagen, and Boswellia extract, in 100 adults with knee osteoarthritis. Participants will take it once daily for 3 months while researchers track changes in pain, stiffness, and daily function us…

This study will test whether high-intensity laser therapy, added to standard physiotherapy, can increase knee cartilage thickness and reduce pain in people with knee osteoarthritis. About 58 adults aged 40-60 with moderate knee OA will receive either laser plus physiotherapy or p…

This trial tests whether a genicular nerve block given before knee replacement surgery can reduce pain and the need for opioids. About 70 adults with knee osteoarthritis will receive either the nerve block or a placebo injection. Researchers will track pain levels, opioid use, an…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study compares two robot-assisted knee replacement methods for people with severe knee arthritis. One method uses a CT scan to plan the surgery (image-based), while the other uses a simpler approach without a scan (imageless). The goal is to see if the imageless method works…

This study tests whether a long-acting painkiller (bupivacaine-meloxicam) can reduce pain and the need for opioid medications after robot-assisted knee replacement. 150 adults with knee osteoarthritis will receive either the new painkiller or a standard injection. Researchers wil…

This study will follow 500 people with knee injuries or knee osteoarthritis who receive standard care at a hospital in China. Researchers will collect medical history, imaging, and function tests at the start and then again at 6, 12, and 24 months. The goal is to better understan…

This study looks at how starting a gradual running program affects knee joint health in people who are new to running, including those with knee osteoarthritis. Researchers will use MRI scans to measure changes in knee cartilage over six months. The goal is to understand whether …