ORAL CANCER

This study is testing whether a short course of antibiotics (metronidazole) and a special mouthwash can lower the amount of bacteria living inside oral cancer tumors. About 30 adults with oral cancer who are scheduled for surgery will take part. The goal is to see if reducing the…

This study tests whether using ultrasound during oral cancer surgery helps surgeons remove tumors more completely. About 150 adults with early-stage oral cancer will be randomly assigned to standard surgery or surgery guided by real-time ultrasound. The goal is to see if ultrasou…

This study compares two non-invasive techniques—a cell-collection brush test and a special microscope—to see if they can accurately detect precancerous and early cancerous spots in the mouth. Researchers will enroll 400 adults with visible mouth lesions. If successful, these meth…

This study is testing a smartphone app that uses artificial intelligence to help people with oral cancer recover and return to work. The app will provide support for physical and emotional symptoms, communication, and exercise. Researchers will compare 650 patients who use the ap…

This study tests if starting tongue strengthening exercises soon after tongue cancer surgery can improve speech and swallowing. About 40 adults who are having part of their tongue removed will use a biofeedback device called the Tongueometer to guide their exercises. The goal is …

This study follows oral cancer patients who completed a previous rehabilitation trial to see if AI-based physiotherapy offers lasting benefits over standard therapy. Researchers will check jaw movement, shoulder function, overall physical health, quality of life, and ability to r…

This study tests whether an AI-powered mobile app can help oral cancer patients recover jaw, shoulder, and overall physical function better than standard care. One hundred patients scheduled for surgery, chemo, or radiation will be split into two groups: one using the AI app for …

This study tests two different pain medicines (dezocine or nalbuphine) given with a standard opioid after oral cancer surgery involving flap reconstruction. The goal is to see which combination provides better pain relief with fewer side effects, and whether it helps the surgical…

This study looks at how stiff the jaw muscles are in people who have had treatment for oral cancer. Using a special ultrasound, researchers will measure muscle hardness and see if it relates to how wide a person can open their mouth. They will also test if exercise can improve mo…

This study looks at whether a simple blood test that finds leftover cancer cells (circulating tumor cells) can help doctors decide which oral cancer patients need extra chemotherapy after their usual treatment. About 100 people who have finished surgery and chemoradiation will be…

This study tests an AI system that uses cameras to measure how well people can move their jaw, neck, and shoulders. Researchers will compare the AI's measurements to standard methods in 40 healthy adults and oral cancer survivors who have stiffness or limited movement after treat…

This study aims to understand how oral cancer causes pain by comparing pressure and stretch sensitivity in 40 cancer patients and 40 healthy volunteers. Researchers will measure pain thresholds and tongue movement discomfort. No treatment is given; the goal is to gather knowledge…

This study looks at whether changes in the bacteria living in your mouth and gut (the microbiome) play a role in head and neck cancer. Researchers will collect stool and saliva samples from 60 adults—some with cancer and some without—to compare their microbiomes. The goal is to u…

This study watches 40 adults having standard oral cancer surgery to learn where infection-causing bacteria come from and how antibiotics work in the body. Researchers will compare bacteria from infections with samples from the mouth, nose, and throat. The goal is to find better w…

This study is for 1000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask participants about their symptoms before, during, and after treatment. The goal is to find better ways to predict how the disease will behave and which tr…

This study aims to learn more about diseases that affect the salivary glands, which produce saliva. Researchers will collect medical information, blood, saliva, and tissue samples from people with these conditions, their relatives, and healthy volunteers. The goal is to better un…

This study checks if an AI-based system can accurately measure jaw and neck-shoulder movement in oral cancer patients. Traditional methods rely on manual measurements, which can vary between raters. The AI uses automated tracking to provide consistent, objective readings. Twenty …

This study tests whether using 3D computer models and printed surgical guides leads to better bone healing than standard free-hand surgery for people needing jaw reconstruction after oral cancer. About 420 adults will be randomly assigned to one of the two methods. The main goal …

This study compares an AI-powered chatbot to traditional educational handouts for teaching African American adults about oral cancer. Researchers want to see which method helps people learn more about prevention, risk factors, and early signs. The goal is to find better ways to s…