METASTATIC LUNG CANCER

This early-phase study tests a new drug called IPH5301 in people with advanced solid tumors that have spread. The drug works by blocking a protein (CD73) that tumors use to hide from the immune system. The study first finds the safest dose of IPH5301 alone, then tests it combined…

This study tests an experimental treatment called OBX-115 for people with advanced melanoma or non-small cell lung cancer that has spread or come back. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified to produce a protein (IL15) t…

This early-phase study tests a new drug called BBO-10203 in people with advanced solid tumors (breast, colorectal, or lung cancer) that have not responded to standard treatments. The drug works by blocking a key cancer growth signal (PI3Kα:RAS). The main goals are to find a safe …

This early-phase study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, and others). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. About 554 …

This early-stage study tests a new drug called BBO-8520 in about 350 adults with advanced non-small cell lung cancer that has a specific genetic change (KRAS G12C). The main goals are to check safety and find the right dose, while also seeing if the drug shrinks tumors. Participa…

This study looks at people with advanced lung cancer who have lived at least three years after diagnosis and are no longer on chemotherapy. Researchers want to learn about their health, quality of life, and social and financial needs. Participants will fill out questionnaires ove…

This study is collecting information and biological samples from 730 adults newly diagnosed with lung cancer. Researchers want to see how patients respond to treatments in everyday medical practice, not just in strict clinical trials. The goal is to better understand the disease …

This study is testing whether a simple blood test (liquid biopsy) can predict how well immunotherapy works in people with advanced lung cancer. Researchers will follow 300 patients who have not yet been treated and are starting immunotherapy, with or without chemotherapy. The goa…

This study looks at memory, mood, and thinking problems that can happen with certain targeted lung cancer pills (ALK/ROS1 inhibitors). Researchers will work with 20 patients to better understand these side effects and how they affect daily life. The goal is to create a better car…