New targeted pill shows promise for tough lung cancer

NCT ID NCT06343402

Recruiting now Disease control Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests an experimental drug called BBO-8520 in 350 people with advanced non-small cell lung cancer that has a specific genetic change (KRAS G12C). The drug is taken as a pill and aims to block cancer growth. The study will check for safety, side effects, and whether the tumor shrinks. Some participants may also receive the drug with other treatments like pembrolizumab.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BBO-8520 (an experimental drug taken orally that targets the KRAS G12C mutation)
What this could lead to: If successful, this could lead to a new treatment option for people with a specific type of advanced lung cancer that has limited targeted therapies.
What could go wrong: This is an early Phase 1 trial, so the drug may not prove safe or effective. Side effects and limited benefit are possible, and it only applies to patients with the KRAS G12C mutation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung carcinoma lung neoplasm metastatic malignant neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED LUNG CARCINOMA KRAS G12C METASTATIC LUNG CANCER METASTATIC NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER NSCLC

Contacts and locations

Locations

Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Henry Ford Cancer - Detroit
RECRUITING

Detroit, Michigan, 48282, United States
Hospital Universitario Quirónsalud Madrid
RECRUITING

Madrid, 28223, Spain
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Juravinski Cancer Centre
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kinghorn Cancer Centre
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Linear Clinical Research
RECRUITING

Nedlands, Western Australia, 6009, Australia
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
NEXT Oncology
RECRUITING

Fairfax, Virginia, 22031, United States
Northwest Medical Specialties
RECRUITING

Tacoma, Washington, 98405, United States
Norwalk Hospital
RECRUITING

Norwalk, Connecticut, 06850, United States
O'Neal Comprehensive Cancer Center at UAB
RECRUITING

Birmingham, Alabama, 35233, United States
OSF Saint Francis Medical Center
RECRUITING

Peoria, Illinois, 61603, United States
Oncology Consultants Texas Medical Center
RECRUITING

Houston, Texas, 77030, United States
Peninsula & South Eastern Hematology and Oncology Group (PAS)
RECRUITING

Frankston, Victoria, 3199, Australia
Perlmutter Cancer Center - NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3051, Australia
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
START Barcelona - Hospital HM Nou Delfos
RECRUITING

Barcelona, 08023, Spain
START Madrid - Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
The Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
The Queen Elizabeth Hospital
RECRUITING

Woodville South, South Australia, 5011, Australia
UCLA Health - Santa Monica Cancer Care
RECRUITING

Santa Monica, California, 90404, United States
USOR - Oncology Associates of Oregon, P.C
RECRUITING

Eugene, Oregon, 97401, United States
USOR - Texas Oncology - (DFW) Waco
RECRUITING

Waco, Texas, 76710, United States
University of California - San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66205, United States
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States

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