MELASMA

This study tests whether taking tranexamic acid pills along with a microneedling procedure that delivers glutathione into the skin works better for melasma than either treatment alone. Forty-two women with facial melasma will be split into groups to compare the approaches. The ma…

This study tests whether a metformin cream or a tranexamic acid cream works better for treating melasma, a skin condition causing dark patches on the face. Seventy adults with melasma will apply one of the creams daily for 12 weeks, along with sunscreen. The main goal is to see w…

This study compares two treatments for melasma, a skin condition causing dark patches on the face. One group gets injections of tranexamic acid, the other gets mandelic acid chemical peels. Researchers will track pigmentation improvement and quality of life in 120 adults over sev…

This study tests whether a cream made from 30% metformin, a common diabetes drug, can treat facial melasma better and with fewer side effects than the standard Kligman's regimen. About 82 women aged 35-55 with melasma will use either the metformin cream or Kligman's regimen plus …

This study compares two creams—tranexamic acid and ethyl ascorbic acid (a form of vitamin C)—for treating melasma, a condition that causes dark patches on the skin. About 128 adults with melasma will use one of the creams, and doctors will measure how much the dark patches improv…

This study tests whether adding MELA B3 serum to a 35% glycolic acid peel works better than the peel alone for treating dark spots (melasma, post-acne marks, age spots) and signs of aging. About 80 adults aged 30-70 in Buenos Aires will use the treatments for 3 months. The goal i…

This early study tests a new gel for melasma, a skin condition causing dark patches on the face. The gel combines three ingredients to lighten spots, reduce inflammation, and help absorption. Ten women aged 18-50 will apply the gel for 12 weeks to see if it improves their skin wi…