LYMPHOPLASMACYTIC LYMPHOMA

This study is testing a specific type of stem cell transplant using donated umbilical cord blood to treat patients with serious blood cancers and disorders. The procedure involves high-dose chemotherapy and radiation to wipe out the patient's diseased bone marrow before infusing …

This study is testing a stem cell transplant from a partially matched family donor for patients with hard-to-treat blood cancers like leukemia and lymphoma. Before the transplant, patients receive chemotherapy and radiation to wipe out their own bone marrow and cancer cells. The …

This study is testing whether a pill called venetoclax can help control a rare type of blood cancer called Waldenström macroglobulinemia in Japanese adults whose cancer has come back or stopped responding to prior treatments. About 14 participants will take the pill daily, with d…

This study is comparing two different drug combination strategies for people newly diagnosed with a rare, slow-growing blood cancer called Waldenström's macroglobulinemia. About 92 participants will be randomly assigned to receive either a combination of ibrutinib and rituximab (…

This early-stage study is testing an experimental drug called MDX2003 for people with several types of B-cell lymphoma that have come back or stopped responding to at least two prior treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. It will…

This study is testing a two-drug combination (acalabrutinib and obinutuzumab) for people with untreated, slow-growing non-Hodgkin lymphomas. The goal is to see if this approach can effectively control the cancer, improve quality of life, and determine if patients who achieve a co…

This is a first-in-human study to test the safety of a new oral drug called SGR-1505 in adults with various types of relapsed or hard-to-treat B-cell cancers, like non-Hodgkin lymphoma and chronic lymphocytic leukemia. The main goal is to find the highest dose patients can tolera…

This is an early-stage study testing the safety of a personalized cell therapy for adults with specific types of non-Hodgkin lymphoma that have come back or not responded to standard treatments. Doctors will modify a patient's own immune cells to better target and fight their can…

This study is testing whether a combination of three drugs—pirtobrutinib, venetoclax, and rituximab—can effectively treat people newly diagnosed with Waldenström's macroglobulinemia, a rare blood cancer. The treatment is given for a limited time rather than continuously. Research…

This study is testing whether the drug pacritinib is safe and effective for people with Waldenström macroglobulinemia, a rare blood cancer, that has come back or stopped responding to other treatments. About 30 participants who have had at least two prior treatments will receive …

This study aims to learn how certain blood cancers develop and change over time. Researchers will follow up to 1,000 adults who have been diagnosed with these conditions, collecting blood and tissue samples regularly. The goal is to understand the biology of these diseases to hel…