LYMPHOPLASMACYTIC LYMPHOMA

This study tests an experimental drug called iopofosine I 131 in people with certain blood cancers (like Waldenstrom macroglobulinemia, multiple myeloma, and lymphoma) that have returned or not responded to prior treatments. The drug delivers radiation directly to cancer cells. A…

This early-stage study tests a DNA vaccine made from patients' own cancer cells to help their immune system fight lymphoplasmacytic lymphoma. Nine participants with asymptomatic disease received the vaccine to find the safest dose and see if it boosts immune response. The goal is…

This study tests a combination of two drugs, ixazomib and rituximab, in people with slow-growing types of B-cell non-Hodgkin lymphoma. The goal is to see how well the drugs shrink or control the cancer. About 33 adults with various subtypes, including follicular lymphoma and chro…

This study tests a new stem cell treatment called MGTA-456 for people with high-risk blood cancers like leukemia and lymphoma. The treatment uses a special process to grow more stem cells from donated umbilical cord blood before transplant. The goal is to help the body rebuild he…

This study looks at whether adding an oral medication (CC-486, or oral azacitidine) to a standard reduced-dose chemo regimen (R-miniCHOP) can help people aged 75 and older with newly diagnosed aggressive B-cell lymphomas. The goal is to see if the combination improves how long pa…

This early-phase study tests a combination of two drugs, copanlisib and nivolumab, in people with Richter's transformation or certain non-Hodgkin lymphomas. The goal is to find the safest dose and see how well the drugs work together. About 27 adults will take part, and the study…

This study looks at how the 'watch and wait' approach affects the quality of life of people with slow-growing lymphomas. Researchers want to know if waiting without treatment causes anxiety or worry. About 250 Korean adults with these cancers will fill out questionnaires to measu…