New immunotherapy MK-1045 enters first human trial for Hard-to-Treat lymphoma
NCT ID NCT06189391
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing a new drug called MK-1045 (CN201) in about 100 people whose B-cell non-Hodgkin lymphoma has returned or stopped responding to treatment. MK-1045 is an immunotherapy designed to help the immune system fight the cancer. The main goals are to check the drug's safety, find the best dose, and see if it shows any signs of working.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MK-1045 (also called CN201), an immunotherapy drug given by IV infusion
What this could lead to
If it works, this could point toward a new treatment option for people with B-cell non-Hodgkin lymphoma that has come back or stopped responding to other therapies.
What could go wrong
This is a very early (Phase 1) trial with only 100 participants, so it is not yet known if MK-1045 is safe or effective. Side effects could be serious, and the drug may not work for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Cancer hospital ( Site 0001)
RECRUITINGBeijing, Beijing Municipality, 100142, China
Contact Phone: •••-•••-••••
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Fifth Medical Center of PLA General Hospital ( Site 0005)
RECRUITINGBeijing, Beijing Municipality, 100071, China
Contact Phone: •••-•••-••••
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Fudan University Shanghai Cancer Center ( Site 0012)
RECRUITINGShanghai, Shanghai Municipality, 200030, China
Contact Phone: •••-•••-••••
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Henan Cancer Hospital ( Site 0009)
RECRUITINGZhengzhou, Henan, 450000, China
Contact Phone: •••-•••-••••
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Jiangxi Cancer Hospital ( Site 0007)
RECRUITINGNanchang, Jiangxi, 330029, China
Contact Phone: •••-•••-••••
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Shandong Cancer Hospital ( Site 0008)
ACTIVE_NOT_RECRUITINGJinan, Shandong, 250117, China
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Shanghai East Hospital ( Site 0002)
RECRUITINGShanghai, Shanghai Municipality, 200120, China
Contact Phone: •••-•••-••••
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Sichuan Cancer Hospital. ( Site 0018)
RECRUITINGChengdu, Sichuan, 610041, China
Contact Phone: •••-•••-••••
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Sun Yat-Sen University Cancer Center ( Site 0003)
RECRUITINGGuangzhou, Guangdong, 510060, China
Contact Phone: •••-•••-••••
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The First Affiliated Hospital of Xiamen University ( Site 0011)
RECRUITINGXiameng, Fujian, 361000, China
Contact Phone: •••-•••-••••
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The First Affiliated Hospital of Zhengzhou University ( Site 0006)
RECRUITINGZhengzhou, Henan, 451161, China
Contact Phone: •••-•••-••••
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The First Hospital Of Jilin University ( Site 0014)
RECRUITINGChangchun, Jilin, 130021, China
Contact Phone: •••-•••-••••
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The Fourth Hospital of Hebei Medical University. ( Site 0004)
RECRUITINGShijiazhuang, Hebei, 050035, China
Contact Phone: •••-•••-••••
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Tianjin Medical University Cancer Institute and Hospital ( Site 0010)
ACTIVE_NOT_RECRUITINGTianjinc, Tianjin Municipality, 300060, China
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Zhongshan Hospital,Fudan University ( Site 0013)
RECRUITINGShanghai, Shanghai Municipality, 200032, China
Contact Phone: •••-•••-••••