LIVER NEOPLASMS

This early-stage study tests a new drug called AST-201 in about 70 adults with advanced solid tumors that have a specific protein (GPC3). The main goal is to check the drug's safety and find the right dose. Researchers will also look at how the drug moves through the body and whe…

This study tests a new medicine (PF-08634404) alone or with another drug (ipilimumab) in adults with advanced liver cancer that cannot be removed by surgery. The goal is to see if the treatment is safe and shrinks tumors. Participants must be 18 or older and have not had prior wh…

This study tests whether adding a precise type of radiation (carbon ion radiotherapy) to standard immunotherapy drugs (atezolizumab and bevacizumab) can better control advanced liver cancer. About 52 adults with liver cancer that cannot be surgically removed will receive this com…

This study is testing a treatment called BSJ019T in 51 Japanese adults with liver cancer that cannot be removed by surgery and has not responded to or is not eligible for standard treatments. The goal is to see if the treatment can control the cancer in the liver and to check for…

This study tests a powerful mix of treatments for people with advanced liver cancer that cannot be surgically removed. The approach combines tumor destruction (ablation), targeted therapy (lenvatinib), immunotherapy (tislelizumab), and a procedure that blocks the tumor's blood su…

This observational study will follow up to 5,000 people with liver tumors who are treated with the HistoSonics Edison system, which uses sound waves (histotripsy) to destroy tumors without needles or surgery. The main goal is to see how well the treatment works right after the pr…

This study is testing whether a special ultrasound done during a liver tumor treatment (called TACE) can show right away if the treatment is working, instead of waiting 1-2 months for an MRI or CT scan. About 266 adults scheduled for TACE will get an ultrasound with a contrast ag…

This study is testing a new imaging method called Contrast Enhanced Super-Resolution (CESR) ultrasound to see if it can better find cancer in the breast, liver, and kidney. About 40 people will take part: 30 patients with known lesions and 10 healthy volunteers to help fine-tune …

This study compares two types of pain relief—spinal and epidural anesthesia—for people having liver surgery. The goal is to see if spinal anesthesia helps control blood pressure better and reduces the need for IV fluids after surgery, while still providing good pain control. The …

This study is looking at whether certain substances in the blood can help doctors predict how well a liver cancer treatment called TACE is working. About 15 adults with liver cancer who are scheduled for TACE will give blood samples before and after treatment. The goal is to see …

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study is testing whether a camera can accurately measure heart rate, blood pressure, and oxygen levels without touching the patient during surgery. About 315 adults having gallbladder, liver, or hernia surgery will participate. The goal is to see if this non-contact method w…