Sound waves zapping liver tumors: new study tracks Real-World success
NCT ID NCT06486454
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is collecting information on how well the HistoSonics Edison System, which uses sound waves (histotripsy) to destroy liver tumors, works in everyday medical practice. Up to 5,000 adults with liver tumors will be followed for up to 5 years after treatment. The main goal is to see how patient and procedure factors affect whether the tumor is successfully treated within 36 hours.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Histotripsy (sound wave therapy) via the HistoSonics Edison System
What this could lead to
If successful, this could show that histotripsy is a safe and effective non-invasive option for treating liver tumors, potentially reducing the need for surgery or radiation.
What could go wrong
This is an observational study, not a controlled trial, so results may be less definitive. Success depends on tumor type and patient factors, and long-term outcomes are still being tracked.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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AdventHealth Altamonte Springs
WITHDRAWNAltamonte Springs, Florida, 32701, United States
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AdventHealth Celebration
RECRUITINGCelebration, Florida, 34747, United States
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Baptist Health Miami Cardiac & Vascular Institute
WITHDRAWNMiami, Florida, 33176, United States
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Henrico Doctors' Hospital
RECRUITINGRichmond, Virginia, 23229, United States
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Henry Ford Health
RECRUITINGDetroit, Michigan, 48202, United States
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Hoag
RECRUITINGNewport Beach, California, 92663, United States
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Lee Health Cancer Institute
RECRUITINGFort Myers, Florida, 33905, United States
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Lehigh Valley Hospital
RECRUITINGAllentown, Pennsylvania, 18103, United States
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Mass General Brigham
RECRUITINGBoston, Massachusetts, 02115, United States
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Miami Valley Hospital South
RECRUITINGCenterville, Ohio, 45459, United States
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Mission Hospital
RECRUITINGMission Viejo, California, 92691, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Northeast Georgia Medical Center
RECRUITINGGainesville, Georgia, 30501, United States
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Novant Health
RECRUITINGWinston-Salem, North Carolina, 27103, United States
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Providence Saint John's Health Center
RECRUITINGSanta Monica, California, 90404, United States
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Providence St. Jude
RECRUITINGFullerton, California, 92835, United States
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RUSH University Medical Center
RECRUITINGChicago, Illinois, 60612, United States
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Renown Regional Medical Center
RECRUITINGReno, Nevada, 89502, United States
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St. David's Medical Center
RECRUITINGAustin, Texas, 78705, United States
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Sutter Bay Hospitals
RECRUITINGSan Francisco, California, 94107, United States
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Swedish Medical Center
RECRUITINGSeattle, Washington, 98122, United States
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The Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
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University of Michigan Health - West
RECRUITINGWyoming, Michigan, 49519, United States
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University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
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University of Wisconsin
RECRUITINGMadison, Wisconsin, 53792, United States
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Weill Cornell Medicine
RECRUITINGNew York, New York, 10065, United States
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Willis Knighton Health
RECRUITINGShreveport, Louisiana, 71103, United States
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