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Sound waves zapping liver tumors: new study tracks Real-World success

NCT ID NCT06486454

Recruiting now Disease control Sponsor: HistoSonics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study is collecting information on how well the HistoSonics Edison System, which uses sound waves (histotripsy) to destroy liver tumors, works in everyday medical practice. Up to 5,000 adults with liver tumors will be followed for up to 5 years after treatment. The main goal is to see how patient and procedure factors affect whether the tumor is successfully treated within 36 hours.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Histotripsy (sound wave therapy) via the HistoSonics Edison System
What this could lead to
If successful, this could show that histotripsy is a safe and effective non-invasive option for treating liver tumors, potentially reducing the need for surgery or radiation.
What could go wrong
This is an observational study, not a controlled trial, so results may be less definitive. Success depends on tumor type and patient factors, and long-term outcomes are still being tracked.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatobiliary benign neoplasm hepatocellular carcinoma liver and intrahepatic bile duct neoplasm liver cancer Liver Neoplasms secondary malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BENIGN LIVER TUMOR LIVER NEOPLASMS PRIMARY LIVER CANCER SECONDARY LIVER CANCER TUMOR LIVER

Contacts and locations

Locations

  • AdventHealth Altamonte Springs

    WITHDRAWN

    Altamonte Springs, Florida, 32701, United States

  • AdventHealth Celebration

    RECRUITING

    Celebration, Florida, 34747, United States

  • Baptist Health Miami Cardiac & Vascular Institute

    WITHDRAWN

    Miami, Florida, 33176, United States

  • Cleveland Clinic Foundation

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • Henrico Doctors' Hospital

    RECRUITING

    Richmond, Virginia, 23229, United States

  • Henry Ford Health

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Hoag

    RECRUITING

    Newport Beach, California, 92663, United States

  • Lee Health Cancer Institute

    RECRUITING

    Fort Myers, Florida, 33905, United States

  • Lehigh Valley Hospital

    RECRUITING

    Allentown, Pennsylvania, 18103, United States

  • Mass General Brigham

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • Miami Valley Hospital South

    RECRUITING

    Centerville, Ohio, 45459, United States

  • Mission Hospital

    RECRUITING

    Mission Viejo, California, 92691, United States

  • NYU Langone Health

    RECRUITING

    New York, New York, 10016, United States

  • Northeast Georgia Medical Center

    RECRUITING

    Gainesville, Georgia, 30501, United States

  • Novant Health

    RECRUITING

    Winston-Salem, North Carolina, 27103, United States

  • Providence Saint John's Health Center

    RECRUITING

    Santa Monica, California, 90404, United States

  • Providence St. Jude

    RECRUITING

    Fullerton, California, 92835, United States

  • RUSH University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

  • Renown Regional Medical Center

    RECRUITING

    Reno, Nevada, 89502, United States

  • St. David's Medical Center

    RECRUITING

    Austin, Texas, 78705, United States

  • Sutter Bay Hospitals

    RECRUITING

    San Francisco, California, 94107, United States

  • Swedish Medical Center

    TERMINATED

    Seattle, Washington, 98122, United States

  • The Ohio State University

    RECRUITING

    Columbus, Ohio, 43210, United States

  • University of Chicago

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Michigan Health - West

    RECRUITING

    Wyoming, Michigan, 49519, United States

    Contact Email: •••••@•••••

  • University of Rochester Medical Center

    RECRUITING

    Rochester, New York, 14642, United States

  • University of Wisconsin

    RECRUITING

    Madison, Wisconsin, 53792, United States

  • Weill Cornell Medicine

    RECRUITING

    New York, New York, 10065, United States

  • Willis Knighton Health

    RECRUITING

    Shreveport, Louisiana, 71103, United States

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