LEPTOMENINGEAL DISEASE
Clinical trials for LEPTOMENINGEAL DISEASE explained in plain language.
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New hope for brain metastases: High-Dose chemo targets lethal spread
Disease control Recruiting nowThis study tests a high dose of the chemotherapy drug methotrexate given through a vein in 16 adults with aggressive breast cancer that has spread to the lining of the brain. The goal is to see if this treatment can help people live longer than 12 weeks. Participants must have a …
Matched conditions: LEPTOMENINGEAL DISEASE
Phase: PHASE2 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated May 17, 2026 05:36 UTC
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New drug cocktail targets breast cancer that invaded the brain
Disease control Recruiting nowThis study tests whether a combination of two oral drugs (tucatinib and capecitabine) plus a chemotherapy given directly into the spinal fluid (trastuzumab) can help people with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord. About 30 adult…
Matched conditions: LEPTOMENINGEAL DISEASE
Phase: PHASE2 • Sponsor: UNICANCER • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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New combo therapy aims to fight deadly breast cancer spread to the brain
Disease control Recruiting nowThis study tests if radiation therapy followed by two targeted drugs (trastuzumab and pertuzumab) given directly into the spinal fluid is safe and helps people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). About 39 p…
Matched conditions: LEPTOMENINGEAL DISEASE
Phase: PHASE1, PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 14, 2026 12:06 UTC
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New german registry aims to shed light on rare brain cancer spread
Knowledge-focused Recruiting nowThis study creates a database to track how often leptomeningeal disease occurs in Germany, how it is treated in real-world settings, and what outcomes patients experience. Researchers will collect information from about 50 adults with this condition to better understand the disea…
Matched conditions: LEPTOMENINGEAL DISEASE
Sponsor: University Hospital Tuebingen • Aim: Knowledge-focused
Last updated May 14, 2026 12:02 UTC