LEPTOMENINGEAL DISEASE
Clinical trials for LEPTOMENINGEAL DISEASE explained in plain language.
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Can a pill reach the brain and fight tumors?
Disease control Not yet recruitingThis trial tests an oral drug called JBI-778 in people with brain metastases, leptomeningeal disease, or recurrent high-grade glioma. The drug is designed to block a protein that may help tumors grow. The study aims to find the safest dose and see if the drug can shrink tumors or…
Matched conditions: LEPTOMENINGEAL DISEASE
Phase: PHASE1, PHASE2 • Sponsor: Jubilant Therapeutics Inc. • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Immune cells engineered to fight brain cancer in kids
Disease control Not yet recruitingThis early-phase study tests the safety of a new cell therapy called B7-H3 CAR T cells for children and young adults whose brain tumors have come back or are growing despite standard treatment. The therapy uses the patient's own immune cells, modified to target a protein (B7-H3) …
Matched conditions: LEPTOMENINGEAL DISEASE
Phase: PHASE1 • Sponsor: Robbie Majzner • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Spinal fluid DNA test could personalize brain cancer therapy
Diagnosis Not yet recruitingThis study explores whether analyzing tumor DNA in cerebrospinal fluid can help doctors make better treatment decisions for people with malignant brain tumors or brain metastases from lung or breast cancer. Participants undergo a standard spinal tap or fluid collection, and the f…
Matched conditions: LEPTOMENINGEAL DISEASE
Phase: NA • Sponsor: Alireza Mansouri • Aim: Diagnosis
Last updated Jul 10, 2026 00:00 UTC