KNEE OSTEOARTHRISTIS

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This Phase 3 trial tests whether a single injection of MAG200 stem cells can improve pain and daily function in adults with knee osteoarthritis. About 573 participants will receive either a low dose, a high dose, or a placebo injection. The study aims to confirm if this approach …

This study tests a physical therapy program designed for older adults with knee osteoarthritis. The program focuses on mobility, balance, and fall prevention, and also considers each person's mental abilities. Forty participants aged 60 and older will take part in 16 sessions ove…

This study tests whether a short, digitally guided exercise program before total knee replacement is practical and helpful. Sixty adults with knee osteoarthritis will either do the 10-14 day program or receive usual care. The main goal is to see if people stick with it and find i…

This study tests whether a special knee and heel brace, combined with strength exercises done while sitting or lying down, can reduce pain and improve walking in people with knee osteoarthritis. Twenty participants will be randomly assigned to get either this new brace or a stand…

This study tests whether combining blood-flow-restricted exercise (light exercise with a cuff on the leg) and pain education can reduce pain and improve movement in people with knee osteoarthritis. About 90 adults aged 40 and older with knee osteoarthritis will take part. The goa…

This study compares a new treatment—focused shockwave therapy—to standard physical rehabilitation for people with mild to moderate knee osteoarthritis. About 60 participants will be randomly assigned to one of the two groups. The goal is to see if shockwave therapy can reduce kne…

This study will look back at medical records of 133 adults aged 40-70 with painful knee osteoarthritis who received a single injection of hyaluronic acid. The goal is to see if one shot can reduce pain, stiffness, and improve function, potentially offering a simpler alternative t…

This study compares two minimally invasive procedures to relieve long-term knee pain from osteoarthritis. One uses radiofrequency (heat) to block pain nerves, the other uses a small amount of alcohol. About 50 adults aged 45-85 with moderate to severe knee pain will be randomly a…

This study compares two ways to restrict blood flow during exercise—using a special floss band or a traditional cuff—to see which better reduces pain and improves movement in people with knee osteoarthritis. 46 adults aged 40-60 with mild to moderate knee OA will do leg exercises…

This study tests two types of leg exercises—closed chain (like mini-squats) and open chain (like leg lifts)—both done with a blood flow restriction cuff on the thigh, in people with mild knee osteoarthritis. Forty participants aged 45-75 will do these exercises plus standard phys…

This study tests whether adding a specific nerve-stretching exercise (femoral nerve mobilization) to standard physical therapy can reduce pain and improve function in people with knee osteoarthritis. Fifty patients aged 50 or older with mild to moderate knee arthritis will be ran…

This study will compare sensory-motor training (exercises that improve how your brain senses joint position) with resistance training (strengthening exercises) in 52 adults aged 40-60 with early-stage knee osteoarthritis (Grade 1 or 2). The goal is to see which approach better re…

This study tests whether wrapping an elastic band around the knee (tissue flossing) combined with simple exercises can reduce pain and improve movement in people with knee osteoarthritis. Fifty-eight adults aged 40-70 with mild to moderate knee OA will be split into two groups: o…

This study will compare two FDA-approved machines that make platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from a person's own blood and is injected into the knee to help with pain and stiffness. The researchers will check if the two machines produce …