IMMUNODEFICIENCY

This study looks at whether using two antiviral drugs together (remdesivir plus nirmatrelvir/r) works better than one drug alone for treating COVID-19 in people with weakened immune systems. It also tests if taking the medication for 10 days instead of 5 helps clear the virus fas…

This study looks at whether giving a combination of two antiviral drugs or a longer treatment course can help people with weakened immune systems clear COVID-19 faster. About 256 participants with mild or no symptoms will receive either standard treatment or an enhanced approach.…

This study tests whether a stem cell transplant from a healthy donor can control VEXAS syndrome, a rare and severe autoinflammatory disease. Up to 54 adults aged 18-75 who have not responded to standard treatments will receive donor stem cells after chemotherapy and possibly radi…

This study tests whether adding a special type of immune cell (memory T cells) after a donor stem cell transplant can help prevent serious viral and fungal infections. It involves up to 100 children and young adults with blood cancers or immune disorders. The approach aims to spe…

This study tests whether a stem cell transplant from a healthy donor can treat GATA2 deficiency, a genetic condition that weakens the immune system and raises the risk of leukemia. Participants aged 6 to 70 receive chemotherapy or radiation before the transplant to prepare their …

This study looks for genes that cause certain immune system problems. It includes up to 5,000 people with known or suspected genetic immune disorders and their family members. Researchers collect blood, cheek swabs, or skin samples to find genetic changes and learn how these cond…

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, can weaken the immune system over time. Researchers will measure immune cells and antibodies in 24 patients before and after 6 months and 1 year of treatment. The goal is to understand i…