HYPERALGESIA

This study tested whether a continuous drip of numbing medicine into the surgical wound for two days after back fusion surgery could reduce pain and speed recovery better than a placebo. Fifty adults having lumbar fusion for degenerative spine disease took part. The goal was to i…

This study tested a one-day educational workshop for people with chronic non-cancer pain who take high doses of opioids. The workshop, led by a team of doctors, psychologists, and pharmacists, provided information on opioid risks and taught coping strategies. Researchers wanted t…

This study tested whether giving ketamine during surgery and methadone after surgery can prevent a condition called opioid-induced hyperalgesia, where painkillers actually make pain worse. 113 patients having open colorectal surgery took part. Researchers measured the area of inc…

This study looked at whether two common pain tests (temporal summation and offset analgesia) give consistent results when used multiple times in healthy adults. 16 volunteers had capsaicin cream applied to their skin to create temporary sensitivity, then the tests were repeated. …

This completed Phase 1 study tested whether 35% nitrous oxide (laughing gas) can reduce pain sensitivity in 20 healthy men. Researchers used electrical stimulation to create temporary pain and measured how the gas affected the area of increased sensitivity. The study also monitor…