HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Clinical trials for HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA explained in plain language.
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Could less radiation be enough for HPV throat cancer?
Disease control OngoingThis study compares a reduced dose of radiation therapy combined with the immunotherapy drug nivolumab against the standard treatment of full-dose radiation plus cisplatin for early-stage HPV-positive oropharyngeal cancer in non-smokers. About 384 participants are enrolled to see…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2, PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jul 02, 2026 06:00 UTC
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Immunotherapy after standard treatment may keep HPV throat cancer at bay
Disease control OngoingThis phase III trial tests whether adding the immunotherapy drug nivolumab after standard chemotherapy and radiation helps people with HPV-positive throat cancer live longer without the cancer growing. About 636 patients with intermediate-risk, locally advanced disease will eithe…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Can less radiation be just as good for HPV throat cancer?
Disease control OngoingThis study looks at whether giving less radiation after surgery for HPV-positive throat cancer can still prevent the cancer from coming back while causing fewer long-term side effects. About 83 adults with HPV-positive oropharyngeal cancer will receive either a standard or reduce…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: NA • Sponsor: Indiana University • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Milder treatment after robotic surgery may cut side effects for HPV throat cancer patients
Disease control OngoingThis study tests a less intense version of standard chemo-radiation for people with HPV-positive throat cancer who have had robotic surgery to remove visible tumors. The goal is to see if the milder treatment works just as well as the standard dose but causes fewer side effects. …
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Cedars-Sinai Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Experimental vaccine plus chemo aims to shrink HPV throat tumors and reduce radiation
Disease control OngoingThis study tests two experimental vaccines (HB-201 and HB-202) given with standard chemotherapy drugs (carboplatin and paclitaxel) to people with HPV16-positive oropharyngeal cancer. The goal is to see if this combination can shrink tumors enough to allow less intensive follow-up…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New combo aims to boost immune attack on HPV-Driven head and neck cancer
Disease control OngoingThis Phase 3 trial tests whether adding an experimental immunotherapy called PDS0101 to the standard drug pembrolizumab helps people with advanced HPV16-positive head and neck cancer live longer. About 252 participants will receive either the combination or pembrolizumab alone. T…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE3 • Sponsor: PDS Biotechnology Corp. • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Could less radiation be just as good for HPV throat cancer?
Disease control OngoingThis study looks at whether giving a lower dose of radiation after robotic surgery can help people with HPV-positive throat cancer have fewer side effects, like trouble swallowing, while still controlling the cancer. About 33 adults with this type of cancer will receive the reduc…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Emory University • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Throat cancer showdown: radiation vs. surgery in HPV patients
Disease control OngoingThis study compares two standard treatments—radiation therapy and surgery—for people with HPV-related throat cancer. The goal is to see which approach provides better survival and quality of life. About 61 adults with early-stage cancer are taking part to help guide future treatm…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: NA • Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Custom immune cells take on multiple cancers in early trial
Disease control OngoingThis early-stage study tests a new treatment called T-Plex for people with advanced solid tumors (like head and neck, cervical, or melanoma) that haven't responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE1 • Sponsor: TScan Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Simple blood test could spot hidden throat cancer
Diagnosis OngoingThis study is testing whether a blood test called NavDx can find HPV-related oropharyngeal cancer early by looking for HPV DNA in the blood. Researchers are enrolling adults aged 45 and older with multiple sexual partners who have no history of this cancer. Participants give bloo…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Diagnosis
Last updated Jun 26, 2026 19:16 UTC
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Can a vaccine stop oral HPV in men with HIV?
Prevention OngoingThis study tests whether the nine-valent HPV vaccine can prevent long-lasting oral HPV infections in men who have HIV. About 700 men will receive either the vaccine or a placebo. The goal is to see if the vaccine reduces new persistent infections with HPV types linked to throat c…
Matched conditions: HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
Phase: PHASE3 • Sponsor: Weill Medical College of Cornell University • Aim: Prevention
Last updated Jun 27, 2026 14:00 UTC