HEPATOBLASTOMA

This early-stage study is testing whether genetically modified immune cells can fight solid tumors in children and young adults. Researchers collect patients' own immune cells, modify them to better recognize and attack cancer cells, then infuse them back into the body. The study…

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific marker called GPC3. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, and then inf…

This early-stage study is testing a new, flavored, oral version of a chemotherapy drug called irinotecan (named Orotecan®) in children and young adults whose solid tumors have come back. The main goals are to find a safe and effective dose and to see how the body processes the dr…

This is a first-in-human study testing a new type of personalized cell therapy for children and young adults (up to age 21) whose solid tumors have come back or haven't responded to standard treatments. Doctors will collect a patient's own immune cells (T cells), genetically modi…

This study is testing a new combination of three drugs—an immunotherapy, a targeted therapy, and a chemotherapy—for children and teenagers with advanced hepatoblastoma, a type of liver cancer, that has come back or hasn't responded to standard treatments. The goal is to see if th…

This study is testing a new chemotherapy plan for children and teenagers with a rare liver cancer called hepatoblastoma. Researchers want to find the best drug combination to improve survival, especially for high-risk cases where current treatments often fail. They will also test…

This research aims to understand the genetic and molecular causes of childhood liver cancers by collecting tissue samples from patients and their families. The study will analyze DNA and tumor tissue to create a better classification system based on biology rather than appearance…