Can a simple injection save Kids' hearing during chemo?

NCT ID NCT04478292

Recruiting now Disease control Sponsor: Shanghai Children's Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a drug called sodium thiosulfate can protect the hearing of children undergoing chemotherapy for hepatoblastoma, a rare liver cancer. About 330 children will be randomly assigned to receive either the hearing-protection drug or a placebo alongside their standard chemo. The goal is to see if it reduces hearing loss without affecting cancer treatment success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sodium thiosulfate
What this could lead to: If it works, this could reduce hearing loss in children undergoing chemotherapy for hepatoblastoma, improving their quality of life.
What could go wrong: This is a phase 3 trial, but results may not confirm benefit. The treatment adds another drug, which could cause side effects or not protect hearing as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatoblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOBLASTOMA

Contacts and locations

Locations

Shanghai Children's Medical Center
RECRUITING

Shanghai, Shanghai Municipality, 200127, China

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