HEALTHY CONTROLS

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to find neuroendocrine tumors. Researchers will scan 200 healthy volunteers and tumor patients using a special tracer that binds to tumor proteins. The goal is to see if the lowe…

This early study is testing whether a gentle, personalized electrical brain stimulation (tACS) is safe and tolerable for pregnant women with depression. Ten participants (5 with depression and 5 healthy) will receive the stimulation and be monitored for side effects and birth out…

This study is testing whether a single session of whole-body heating, with or without a cold water plunge, can reduce symptoms of depression. Researchers will recruit 162 adults aged 18-65 who currently have depressive symptoms. Participants will be randomly assigned to receive e…

This study tests whether a technique called Graded Motor Imagery (GMI) — a series of mental exercises — can reduce pain, stiffness, and instability in people with chronic ankle instability. About 48 participants (half with ankle issues, half healthy) will perform GMI and have the…

This study is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of a protein called alpha-synuclein in the brain using PET scans. Researchers will scan 40 people, including those with Parkinson's disease, multiple system atrophy, dementia with Lewy …

This study tests a new, non-invasive brain stimulation technique called transcranial interference stimulation (tIS) in 10 healthy adults. The goal is to see if it is safe and how it affects brain activity and emotion recognition. If successful, this research could lead to future …

This study uses a special brain scan (PET) to compare the density of connections between brain cells in people with cocaine use disorder versus healthy volunteers. Researchers aim to understand how cocaine affects brain wiring. Participants undergo imaging and assessments, but no…

This study is creating a large collection of samples (like stool, saliva, and skin swabs) from up to 600 people of all ages, both healthy and with various conditions. The goal is to help researchers learn how the tiny organisms living in and on our bodies affect our health and pl…

This study looks at how two rare diseases that cause blood vessel inflammation—Takayasu arteritis and Behçet's disease—affect physical strength, breathing, daily function, and emotional well-being. Researchers will compare 30 participants (patients and healthy volunteers) using s…

This study uses brain scans (fMRI) to understand why people with bipolar disorder experience unstable moods. Researchers will compare 72 adults—some with bipolar disorder and some healthy—while they recall personal memories and practice boosting positive feelings. The goal is to …

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy people. …

This study looks at how haloperidol, an antipsychotic medication, may interfere with insulin's normal action in the brain. Insulin helps control blood sugar and supports brain function, but long-term use of haloperidol can lead to weight gain and diabetes. Researchers will give h…

This study looks at how a supplement called HA35 affects muscle protein in healthy adults. Twenty-four participants will take either HA35 or a placebo for three days, then complete a four-hour visit that includes blood tests, muscle biopsies, and a gut permeability test. The goal…

This study looks at why people with Lewy body dementia (including Parkinson's disease dementia) experience sudden, unpredictable changes in attention and thinking, known as cognitive fluctuations. Researchers will use brain scans, EEG, and thinking tests to measure brain changes …

This study explores whether very small, barely noticeable movements can retrain the brain's balance system in people with inner ear disorders. Researchers will measure balance and motion perception in 48 adults with certain types of dizziness or balance loss, as well as healthy v…

This study tests if special smart socks (DANU) can accurately measure walking and balance in people with Parkinson's. Researchers will compare results from 60 participants (30 with Parkinson's and 30 healthy older adults) during a single lab visit. The goal is to see if sock data…

This study uses low-intensity focused ultrasound to safely and temporarily change how different parts of the brain communicate in healthy volunteers. Researchers will test different doses to see which has the strongest effect on brain networks linked to mood and anxiety. The goal…