HEALTHY CONTROLS

This study tests a new PET imaging method that uses much less radiation to find neuroendocrine tumors. About 200 healthy volunteers and people with these tumors will get an injection of a radioactive tracer and be scanned on a high-sensitivity PET machine. The goal is to see if t…

This early study tests a new, personalized brain stimulation method (tACS) for depression during pregnancy. Ten women (5 with depression and 5 healthy) will receive the treatment to see if it is safe, tolerable, and practical. The goal is to gather initial data to guide larger fu…

This pilot study tests whether a mental exercise program called Graded Motor Imagery can help people with chronic ankle instability. Over six days, participants will practice ankle recognition tasks, imagine moving their ankle, and use mirror therapy. The study compares results b…

This study tests whether a single session of whole-body heat therapy (using an infrared sauna) with or without a cold water plunge can reduce depression symptoms. Researchers will enroll 162 adults with depressive symptoms and track their mood changes over two weeks. The goal is …

This study is creating a large collection of microbiome samples—like stool, saliva, and skin swabs—from 600 people of all ages, including healthy volunteers and those with various illnesses. The goal is to build a resource for future research on how the microbiome affects health …

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This study tests a new device called transcranial interference stimulation (tIS) in 10 healthy adults. The goal is to see if it is safe and can change brain activity related to recognizing emotions in faces. If it works, this approach might one day help people with conditions lik…

This study uses brain scans (fMRI) to understand why people with bipolar disorder experience unstable moods compared to healthy individuals. Researchers will ask 72 participants to recall personal memories and practice boosting positive feelings while their brain activity is reco…

This study looks at how the antipsychotic medication haloperidol may block insulin action in the brain, which could explain why these drugs often cause weight gain and diabetes. Researchers will give healthy volunteers either haloperidol or a placebo and use brain scans to measur…

This study explores whether very small, barely noticeable movements can help retrain the brain's balance system in people with inner ear problems. Researchers will test balance and motion sensitivity in 48 adults with certain balance disorders and healthy volunteers. The goal is …

This study looks at why people with Lewy body dementia have sudden changes in attention and thinking, called cognitive fluctuations. Researchers will use skin biopsies, brain scans, and EEG monitoring in 120 participants to link these symptoms to damage in a key brain chemical sy…

This observational study tests whether DANU Smart Socks can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare data from 60 participants (30 with Parkinson's and 30 healthy older adults) during a single lab visit. The goal is to se…

This early-phase study tests a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. Researchers will scan 40 volunteers, including healthy people and those with Parkinson's disease, multiple system atrophy…

This study looks at how two rare diseases that cause blood vessel inflammation—Takayasu arteritis and Behçet's disease—affect physical strength, breathing, daily function, and emotional well-being. Researchers will compare 30 participants (patients and healthy volunteers) using s…

This early-stage trial at the Cleveland Clinic is studying how a specific type of hyaluronic acid (HA35) affects muscle protein in 24 healthy adults. Participants take either HA35 or a placebo capsule for three days, then undergo tests including muscle biopsies and a gut permeabi…

This study uses low-intensity focused ultrasound to temporarily change activity in deep brain areas involved in mood and anxiety. Researchers will scan the brains of 66 healthy adults before and after ultrasound to see how it alters communication between key regions. The goal is …

This study uses PET scans with a special tracer to measure brain synapse density in 80 people—some with cocaine use disorder and some healthy controls. Researchers aim to see if cocaine changes brain connections, especially in areas linked to decision-making and addiction. Partic…