GONARTHROSIS

This study tests whether a new nerve block (quadri-block) helps people recover better after total knee replacement compared to the usual method (adductor canal block plus surgical infiltration). One hundred adults with knee arthritis scheduled for knee replacement will be randoml…

This study tests whether taking nefopam, a non-opioid painkiller, by mouth before and after knee replacement surgery can reduce pain and the need for morphine. About 50 adults having knee replacement will be randomly assigned to receive either nefopam or a placebo. The goal is to…

This study compares two pain-relief methods after total knee replacement: a single injection into the adductor canal versus a continuous nerve block in the thigh. The goal is to see which approach helps patients walk farther and recover faster without increasing fall risk. About …

This study compares two ways of giving platelet-rich plasma (PRP) injections for chronic knee osteoarthritis: one into the joint only, and another that also targets tissues around the knee. Researchers want to see if the combined approach better reduces pain, improves daily funct…

This study tests whether high-intensity pulsed electromagnetic field (HI-PEMF) therapy can reduce pain and improve strength in older adults with knee osteoarthritis. 64 participants will receive HI-PEMF on the knee alone or on both the knee and thigh muscle, plus a home exercise …

This study compares two ways to perform total knee replacement: the standard manual technique versus one guided by computer-assisted navigation. Researchers will enroll 160 patients and measure pain, function, blood loss, and costs. The goal is to see if the computer-assisted met…

This study compares two ways of tracking recovery after knee replacement surgery: traditional paper questionnaires filled out at the clinic versus digital surveys sent to a patient's smartphone. Researchers will enroll 50 adults aged 18-78 who own a smartphone, tablet, or compute…