GLIOBLASTOMA (GBM)

This study tests a new treatment using natural killer (NK) cells, a type of immune cell, for adults with aggressive brain tumors that have not responded to standard therapies. The NK cells are grown in a lab and then given through a vein and directly into the brain. The main goal…

This study tests whether a drug called G-CSF (filgrastim) can help protect brain structure and thinking skills in people with a specific type of glioblastoma (MGMT-methylated). About 60 participants will receive either standard chemoradiation alone or with added G-CSF. The goal i…

This study tests whether adding a new immune cell treatment (DOC1021) to standard therapy helps people with a newly diagnosed, aggressive brain cancer called glioblastoma live longer. About 180 adults will either get the immune treatment plus standard care, or standard care alone…

This study tests whether a higher daily dose of radiation over three weeks can improve survival and quality of life for adults aged 65 and older with newly diagnosed glioblastoma, an aggressive brain cancer. About 56 participants will be randomly assigned to receive either standa…

This early-phase trial tests a new treatment for newly diagnosed glioblastoma, a fast-growing brain cancer. The therapy uses donor stem cells that carry a 'suicide gene' and are injected into the brain after tumor removal. The goal is to see if it is safe and can kill leftover ca…

This trial tests a new gene therapy called TGX-007 for people with a fast-growing brain cancer called glioblastoma. The therapy uses a harmless virus to deliver two special instructions into the tumor: one helps a common antiviral drug kill cancer cells, and the other wakes up th…

This study tests a new drug called MT-125 given together with standard radiation for people newly diagnosed with a fast-growing brain tumor called glioblastoma. The main goals are to find a safe dose and understand side effects. About 36 adults aged 18 and older with a specific t…

This study tests whether adding a chemotherapy drug (thiotepa) injected into the spinal fluid can help control glioblastoma that has spread to the brain's lining or fluid spaces. About 38 adults with newly diagnosed, aggressive brain tumors will receive standard treatments plus t…

This study is developing a blood test that uses artificial intelligence to find cancer early and track how well treatment is working. Researchers will analyze blood samples from 6,000 adults with or without cancer to identify unique signals in platelets and immune cells. The goal…

This study aims to understand why some glioblastoma patients may think about suicide. Researchers will use questionnaires to track depression, anxiety, and quality of life in 176 adults with this aggressive brain tumor. The goal is to identify factors that could help doctors prov…

This study is testing whether a dye called 5-ALA, which makes brain tumor cells glow during surgery, can also help detect tumor signals in the blood and urine. Researchers will take samples from 30 adults with glioblastoma or other brain tumors before and after the dye is given. …

This study is testing a new approach to personalize treatment for people with a fast-growing brain tumor called glioblastoma. Researchers will use a lab test on tumor cells to see which drugs might work best for each patient. The goal is to find out if this method can help more p…