FRONTOTEMPORAL DEMENTIA

This study tests a new gene therapy called AVB-101 for people with a rare, inherited form of frontotemporal dementia (FTD-GRN). The treatment is given once directly into the brain to restore a missing protein and potentially slow or stop the disease. About 18 adults aged 30-75 wi…

This study is testing a new, non-invasive eye scan that uses different colors of light to look for signs of brain diseases like Alzheimer's, Parkinson's, and dementia. Researchers will scan the retinas of 930 adults over 30, including those with these conditions and healthy volun…

This study tests whether the drug vortioxetine can improve mood symptoms and thinking skills in people with early-stage behavioral variant frontotemporal dementia (bvFTD). Participants will take the medication for 12 weeks and undergo brain scans and memory tests before and after…

This study tests a non-invasive brain stimulation technique called tACS in 200 people with Alzheimer's, Lewy body dementia, frontotemporal dementia, or normal pressure hydrocephalus. Participants receive either real or sham stimulation four times daily, and researchers measure ch…

This study tests a video-based program called STELLA-FTD that helps family members caring for a loved one with frontotemporal dementia (FTD). The program teaches caregivers how to manage difficult behaviors and connect with community resources. Researchers will enroll 640 caregiv…

This study uses special eye cameras to take detailed pictures of the back of the eye in 2000 adults with and without brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. The goal is to find changes in the eye that might signal early signs of these conditions. No …

This study is for 500 adults with early dementia or mild cognitive impairment. Researchers will collect blood samples and run cognitive tests over time to build a model that predicts how each person's disease will progress. The goal is to give patients and doctors more accurate i…

This study follows 20 people from families with a genetic risk for frontotemporal dementia (FTD), including those already diagnosed and those at risk. Over five years, researchers will track changes in health and brain function to better understand how the disease develops. The g…

This study looks at whether special brain cells called tanycytes play a role in Alzheimer's disease and frontotemporal dementia. Researchers will measure hormone levels in blood and spinal fluid from 102 participants to see if these cells help control metabolism and hormone signa…

This study aims to learn more about neurodegenerative disorders such as ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will screen 360 adults with these conditions using tests like memory exams, movement analysis, MRI scans, and genetic testing. The…