END STAGE RENAL DISEASE (ESRD)

This early-phase study tests whether a patient's own fat-derived stem cells, applied during surgery, can prevent dialysis fistulas from failing. About 74 adults with end-stage kidney disease who need a new fistula will take part. The goal is to see if the stem cells help keep the…

This study looks at whether giving testosterone to men with low testosterone and end-stage kidney disease before a kidney transplant can help them recover better and more safely. About 50 men will receive testosterone therapy for at least 3 months before their transplant, and the…

This study tests whether a dialysis solution containing amino acids can improve the nutritional health of adults with end-stage kidney disease who are already on peritoneal dialysis. Fifty participants will replace one daily dialysis bag with the amino acid solution for six month…

This study looks at whether adding a structured exercise program during dialysis sessions can help people with end-stage kidney disease improve their muscle strength, walking ability, and overall quality of life. About 60 patients will either receive dialysis alone or dialysis pl…

This study tests two local anesthetics, ropivacaine and lidocaine, in 40 adults with end-stage kidney disease who need surgery to create a vein access for dialysis. Neither patients nor surgeons know which drug is used. The goal is to see which provides better pain control during…

This study looks at whether making changes at the health system level can help more people with end-stage kidney disease start the process of getting a kidney transplant. Researchers will work with five large transplant centers and about 800 dialysis centers to see if these chang…

This study looks at how the drug LY3537031 moves through the body in people with different levels of kidney function. About 32 adults—some with kidney problems and some healthy—will receive a single dose. The goal is to learn how the kidneys affect drug levels and safety, not to …